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Transient receptor potential channels (TRP channels)

StructureProduct infoAvailabilityQuantity / Price
BRC0981
Product IDBRC0981
Product classBioreference compound
CAS number103-90-2
MW151.2
Synonyms
NSC-109028; NSC-3991; APAP; Acenol; Paracetamol;
Transport conditionsNormal

Acetaminophen

Acetaminophen is a widely used analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. It is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin synthesis.

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BRC0815
Product IDBRC0815
Product classBioreference compound
CAS number2216-51-5
MW156.3
Synonyms
NPO-11; NSC-62788;
Transport conditionsNormal

Menthol

Menthol is local anesthetic and counterirritant, and it is widely used to relieve minor throat irritation. Menthol triggers cold-sensitive TRPM8 receptors in the skin neurons in vitro.

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BRC0969
Product IDBRC0969
Product classBioreference compound
CAS number97-53-0
MW164.2
Synonyms
NSC-209525; NSC-8895; 4-allylguaiacol;
Transport conditionsNormal

Eugenol

Eugenol is an antifungal and antimicrobial agent, TRPV1 receptor agonist. Its exact mechanism of action is unknown, however, it has been shown to interfere with action potential conduction.

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BRC0460
Product IDBRC0460
Product classBioreference compound
CAS number51314-51-3
MW189.3
Synonyms
Transport conditionsNormal

NSC 139486

Transient receptor potential canonical (TRPC) channel inhibitor.

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BRC0529
Product IDBRC0529
Product classBioreference compound
CAS number5465-86-1
MW226.3
Synonyms
NSC 25850, CID-230710, 2-piperidino-Lepidine
Transport conditionsNormal

ML 204

ML-204 is a selective blocker of transient receptor potential canonical 4 (TRPC4) channels (IC50s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It demonstrates 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 μM.

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BRC0244
Product IDBRC0244
Product classBioreference compound
CAS number57-66-9
MW285.4
Synonyms
Benemid, Proben, NSC 18786
Transport conditionsNormal

Probenecid

Probenecid inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels. Probenecid may also reduce plasma binding of urate and inhibit renal secretion of uric acid at subtherapeutic concentrations.

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BRC0459
Product IDBRC0459
Product classBioreference compound
CAS number254753-54-3
MW292.4
Synonyms
Transport conditionsNormal

Monastrol

Monastrol is a cell-permeable, potent, small molecule mitosis inhibitor that does not interact with tubulin.

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BRC0518
Product IDBRC0518
Product classBioreference compound
CAS number2444-46-4
MW293.4
Synonyms
8-Nordihydrocapsaicin, AH 23491X, NSC 172795, Pseudocapsaicin
Transport conditionsNormal

Nonivamide

Nonivamide is an capsaicinoid. Like capsaicin, it can deter mammals (but not birds or insects) from consuming plants or seeds. Nonivamide is a TRPV1 ion channel agonist. Mammalian TRPV1 is activated by heat and capsaicin, but the avian form is insensitive to capsaicin.

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BRC0810
Product IDBRC0810
Product classBioreference compound
CAS number581809-67-8
MW345.3
Synonyms
Transport conditionsNormal

A-425619

A-425619 is potent TRPV1 antagonist (IC50 = 3-9 nM). It blocks capsaicin-evoked currents in rat DRG neurons and inhibits TRPV1-activation by anandamide and N-arachidonoyl-dopamine. Reduces pain in inflammatory, postoperative and osteoarthritic in vivo pain models.

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BRC0338
Product IDBRC0338
Product classBioreference compound
CAS number349085-38-7
MW355.4
Synonyms
TOSLAB 829227
Transport conditionsNormal

HC-030031

HC-030031 is a substituted theophylline derivative. Potent and selective ANKTM1 (TRPA1) inhibitor. It antagonizes allyl isothiocyanate (AITC)- and formalin-evoked calcium influx with IC50 values of 6.2 and 5.3 μM respectively.

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BRC0565
Product IDBRC0565
Product classBioreference compound
CAS number702636-90-6
MW423.5
Synonyms
Transport conditionsNormal

SID 2848719

SID 2848719 is TRPM5 modulator.

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BRC0879
Product IDBRC0879
Product classBioreference compound
CAS number1263068-83-2
MW481.5
Synonyms
Transport conditionsNormal

GSK 205

GSK 205 is a TRPV4 inhibitor (IC50 = 0.6 µM).

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