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Ligand-gated ion channels

StructureProduct infoAvailabilityQuantity / Price
BRC0254
Product IDBRC0254
Product classBioreference compound
CAS number142-63-2
MW86.1
Synonyms
Diethylenediamine, Piperazidine, Piperazin, Antepar, Uvilon, Vermidol, Vermizine
Transport conditionsNormal

Piperazine Hexahydrate

Piperazine is a GABA receptor agonist.

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BRC1419
Product IDBRC1419
Product classBioreference compound
CAS number107-97-1
MW89.1
Synonyms
Methylglycine; N-Methylaminoacetic acid; Sarcosin; Sarcosinic acid;
Transport conditionsNormal

Sarcosine

Sarcosine is an endogenous inhibitor of GlyT1 with antipsychotic activity. It potentiates the action of glycine on the NMDA glycine binding site.

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BRC1147
Product IDBRC1147
Product classBioreference compound
CAS number22059-21-8
MW101.1
Synonyms
ACC; NSC 98430;
Transport conditionsNormal

ACPC

ACPC is NMDA receptor activity modulator, acts as a partial agonist at the glycine-binding site on NMDA receptors (EC50 = 0.7-0.9 µM) in the presence of low levels (1 µM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 µM) of glutamate.

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BRC1245
Product IDBRC1245
Product classBioreference compound
CAS number98-79-3
MW129.1
Synonyms
NSC 143034; Oxoproline; Glutiminic acid; Pidolidone; Pidolic Acid;
Transport conditionsNormal

L-Pyroglutamic acid

L-Pyroglutamic acid is an amino acid that is used in the synthesis of peptides. It is cyclooxygenase inhibitor.

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BRC0928
Product IDBRC0928
Product classBioreference compound
CAS number68506-86-5
MW129.2
Synonyms
CPP-109; MDL 71,754; MDL-71754; RMI-71754; GVG; Sabril™; γ-Vinyl GABA;
Transport conditionsNormal

Vigabatrin

Vigabatrin is a structural analogue of gamma-aminobutyric acid, irreversible inhibitor of 4-aminobutyrate transaminase, the enzyme responsible for the catabolism of gamma-aminobutyric acid.

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BRC1068
Product IDBRC1068
Product classBioreference compound
CAS number3544-24-9
MW136.2
Synonyms
NSC 36962; SR 4294; WD 97-000835;
Transport conditionsNormal

INO-1001

INO-1001 is PARP (poly(ADP-ribose) polymerase) inhibitor (Ki = 1.8 μM), which protects cells from UV-B-induced apoptosis via influence on the cytoskeleton. Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.

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BRC1417
Product IDBRC1417
Product classBioreference compound
CAS number3687-18-1
MW139.2
Synonyms
Alzhemed; Homotaurine; NC 758; NSC 77071; γ-Aminopropylsulfonic acid;
Transport conditionsNormal

Tramiprosate

Tramiprosate is a GABA mimetic that targets soluble amyloid β (Aβ) and maintains Aβ in a non-fibrillar form. Decreases Aβ42-induced neuronal death and inhibit amyloid deposition in vitro. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also, a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo.

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BRC1029
Product IDBRC1029
Product classBioreference compound
CAS number59-50-7
MW142.6
Synonyms
NSC 4166; Neopredisan; Parol; Raschit; PCMC;
Transport conditionsNormal

Chlorocresol

Chlorocresol is a chlorinated phenol which is used as an antiseptic and preservative.

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BRC0888
Product IDBRC0888
Product classBioreference compound
CAS number4424-20-8
MW147.2
Synonyms
Transport conditionsNormal

5-Azabenzocycloheptene

5-Azabenzocycloheptene is a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.

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BRC1302
Product IDBRC1302
Product classBioreference compound
CAS number62306-84-7
MW153.6
Synonyms
Transport conditionsNormal

3-methyl-GABA hydrochloride

3-methyl-GABA hydrochloride is activator of GABA aminotransferase.

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BRC1033
Product IDBRC1033
Product classBioreference compound
CAS number64-65-3
MW155.2
Synonyms
Mikedimide; NP 13; NSC 168667; NSC 58187; Zentraleptin;
Transport conditionsNormal

Bemegride

Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning as its chemoreceptor agonism increases mean tidal volume, thereby increasing respiration and the concentration of O2 in blood.

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BRC1079
Product IDBRC1079
Product classBioreference compound
CAS number88-04-0
MW156.6
Synonyms
PCMX; Parametaxylenol; RBA 777;
Transport conditionsNormal

Chloroxylenol

Chloroxylenol is an antiseptic and disinfectant agent used for skin disinfection and cleaning surgical instruments.

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BRC0582
Product IDBRC0582
Product classBioreference compound
CAS number487-19-4
MW158.2
Synonyms
NSC 127943, NSC 407276
Transport conditionsNormal

β-Nicotyrine

β-Nicotyrine is an alkaloid metabolite of nicotine. It binds CYP2A6 (IC50 = 2200nM), which is prominently involved in the metabolism of xenobiotics in the airways.

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BRC0909
Product IDBRC0909
Product classBioreference compound
CAS number182485-36-5
MW161.1
Synonyms
Transport conditionsNormal

TPMPA

TPMPA is GABA receptor antagonist.

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BRC0818
Product IDBRC0818
Product classBioreference compound
CAS number616-91-1
MW163.2
Synonyms
5052; NSC-111180; RK-0202; NAC; Mercapturic acid;
Transport conditionsNormal

Acetylcysteine

Acetylcysteine (NAC) is an antioxidant and precursor of glutathione that has multiple effects in cells and animals. It is primarily used as a mucolytic agent and in the management of acetaminophen poisoning. It is essentially a prodrug that is converted to cysteine (in the intestine by the enzyme aminoacylase 1) and absorbed in the intestine into the bloodstream. As an antioxidant, NAC scavenges hydrogen peroxide, hydroxyl radical, and hypochlorous acid.

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BRC0692
Product IDBRC0692
Product classBioreference compound
CAS number76-38-0
MW165.0
Synonyms
DA-759; NSC-110432;
Transport conditionsNormal

Methoxyflurane

Methoxyflurane is an anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability.

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BRC1066
Product IDBRC1066
Product classBioreference compound
CAS number498-02-2
MW166.2
Synonyms
NSC 209524; NSC 2146;
Transport conditionsNormal

Apocynin

Apocynin is a methoxy-substituted catechol that is commonly used as a selective NADPH-oxidase inhibitor with IC50 of 10 μM. Acts as an antioxidant in endothelial cells and vascular smooth muscle cells.

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BRC0189
Product IDBRC0189
Product classBioreference compound
CAS number60142-96-3
MW171.2
Synonyms
Gabapentin GR, Neurontin, Aclonium
Transport conditionsNormal

Gabapentin

Gabapentin interacts with cortical neurons at auxillary subunits of voltage-sensitive calcium channels. Gabapentin increases the synaptic concentration of GABA, enhances GABA responses at non-synaptic sites in neuronal tissues, and reduces the release of mono-amine neurotransmitters.

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BRC0466
Product IDBRC0466
Product classBioreference compound
CAS number87-52-5
MW174.2
Synonyms
Donaxine, NSC 16892
Transport conditionsNormal

Gramine

Gramine is a naturally occurring indole alkaloid present in several plant species. Has been found to act as an agonist of the adiponectin receptor 1 (LD50 = 44.6 - 62.9 mg/kg). Gramine is a norepinephrine reuptake inhibitor in synaptic vesicles.

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BRC0615
Product IDBRC0615
Product classBioreference compound
CAS number2078-54-8
MW178.3
Synonyms
ICI 35868; Disoprivan; Disoprofol;
Transport conditionsNormal

Propofol

Propofol is a sedative-hypnotic agent for use in the induction and maintenance of anesthesia or sedation. It acts as a potentiator of the GABAA receptor.

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BRC0687
Product IDBRC0687
Product classBioreference compound
CAS number13838-16-9
MW184.5
Synonyms
Anesthetic 347; Alyrane;
Transport conditionsNormal

Enflurane

Enflurane is an anesthetic. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. Enflurane acts as a positive allosteric modulator of the GABAA, glycine, and 5-HT3 receptors, and as a negative allosteric modulator of the AMPA, kainate, and NMDA receptors, as well as of nicotinic acetylcholine receptors.

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BRC0823
Product IDBRC0823
Product classBioreference compound
CAS number26675-46-7
MW184.5
Synonyms
R-E 235da1, HCFE 235da2,
Transport conditionsNormal

Isoflurane

Isoflurane is a general inhalation anesthetic. It induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times.

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BRC0260
Product IDBRC0260
Product classBioreference compound
CAS number665-66-7
MW187.7
Synonyms
Aminoadamantane, Viregyt, Virosol, PK-Merz, Symadine, Symmetrel
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Amantadine hydrochloride

Amantadine is an antiviral drug which also acts as an antiparkinson agent, for which it is usually combined with L-DOPA when L-DOPA responses decline (probably due to tolerance).

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BRC0023
Product IDBRC0023
Product classBioreference compound
CAS number62-31-7
MW189.6
Synonyms
3-Hydroxytyramine, Deoxyepinephrine, Oxytyramine, Intropin, Revimine
Transport conditionsNormal

Dopamine hydrochloride

Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility.

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BRC1077
Product IDBRC1077
Product classBioreference compound
CAS number94-26-8
MW194.2
Synonyms
NSC 13164; NSC 8475; Nipabutyl; SPF;
Transport conditionsNormal

Butylparaben

Butylparaben is an antifungal preservative in cosmetic products.

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BRC0595
Product IDBRC0595
Product classBioreference compound
CAS number67730-11-4
MW198.2
Synonyms
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Glu-P1

Glu-P1 is an mutagenic compound.

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BRC1074
Product IDBRC1074
Product classBioreference compound
CAS number153322-05-5
MW198.3
Synonyms
ARL 15896; FPL 15896; AR-R15896; AZD6765;
Transport conditionsNormal

Lanicemine

Lanicemine is a non-selective, voltage-dependent NMDA channel blocker (IC50 = 4-7 µM). It has been used in trials studying the treatment and basic science of Depression, Major Depressive Disorder, and Treatment-Resistant Major Depressive Disorder.

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BRC0550
Product IDBRC0550
Product classBioreference compound
CAS number19772-76-0
MW199.2
Synonyms
DL-Willardiine
Transport conditionsNormal

(±)-Willardiine

(±)-Willardiine is a selective inhibitor of specific binding of [3H]AMPA to Ionotropic glutamate receptor AMPA (IC50 = 1800 nM).

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BRC0857
Product IDBRC0857
Product classBioreference compound
CAS number28523-86-6
MW200.1
Synonyms
Transport conditionsNormal

Sevoflurane

Sevoflurane is one of the most commonly used volatile anesthetic agents, particularly for outpatient anesthesia, across all ages, as well as in veterinary medicine.

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BRC1178
Product IDBRC1178
Product classBioreference compound
CAS number209185-99-9
MW205.8
Synonyms
Transport conditionsNormal

Neramexane hydrochloride

Neramexane hydrochloride is an NMDA antagonist with neuroprotective effects. It targets the cognitive decline in Alzheimer’s Disease by altering neurotransmitter signaling. Neramexane also acts as a nicotinic acetylcholine receptor antagonist.

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BRC0032
Product IDBRC0032
Product classBioreference compound
CAS number41100-52-1
MW215.8
Synonyms
Abixa, Akatinol, Axura, Memox
Transport conditionsNormal

Memantine hydrochloride

Memantine exerts its action through uncompetitive NMDA receptor antagonism, binding preferentially to the NMDA receptor-operated cation channels. Memantine also has antagonistic activity at the type 3 serotonergic (5-HT3) receptor with a potency that is similar to that at the NMDA receptor, and lower antagonistic activity at the nicotinic acetylcholine receptor. This drug has no affinity for γ-aminobutyric acid (GABA), benzodiazepine, dopamine, adrenergic, histamine, or glycine receptors or for voltage-dependent calcium, sodium, or potassium channels.

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BRC0226
Product IDBRC0226
Product classBioreference compound
CAS number125-33-7
MW218.3
Synonyms
Desoxyphenobarbital, Mysoline, Liskantin, Mizodin, Mylepsinum, Pridona, Primid, Prysoline, Sertan
Transport conditionsNormal
Restrictions Included in DEA controlled list Restriction

Primidone

An antiepileptic agent related to the barbiturates; it is partly metabolized to phenobarbital in the body and owes some of its actions to this metabolite. Primidone is a GABA receptor agonist.

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BRC0529
Product IDBRC0529
Product classBioreference compound
CAS number5465-86-1
MW226.3
Synonyms
NSC 25850, CID-230710, 2-piperidino-Lepidine
Transport conditionsNormal

ML 204

ML-204 is a selective blocker of transient receptor potential canonical 4 (TRPC4) channels (IC50s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It demonstrates 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 μM.

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BRC1320
Product IDBRC1320
Product classBioreference compound
CAS number2482-00-0
MW228.3
Synonyms
NIH 11035; NSC 56332;
Transport conditionsNormal

Agmatine sulfate

Agmantine is a natural metabolite of the arginine. It binds to human adrenergic receptors and imidazoline (I) receptors. Agmatine acts as an antagonist of the NMDA receptor and nicotinic acetylcholine receptors. It is an antagonist of the serotonin receptor subtype 5-HT3 and blocks ATP-sensitive potassium channels. Agmatine competitively inhibits neuronal, macrophage, endothelial, and inducible nitric oxide synthase and irreversibly inactivates neuronal NOS in the presence of calmodulin.

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BRC0239
Product IDBRC0239
Product classBioreference compound
CAS number25451-15-4
MW238.2
Synonyms
Taloxa, ADD-03055
Transport conditionsNormal

Felbamate

Felbamate is an anticonvulsant drug used in the treatment of epilepsy. It has a weak inhibitory effect on GABA receptor binding sites.

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BRC0445
Product IDBRC0445
Product classBioreference compound
CAS number33125-97-2
MW244.3
Synonyms
Lipuro, Propiscin, R 16659, Hypnomidate, Amidate
Transport conditionsNormal

Etomidate

Etomidate is an imidazole compound that appears to depress CNS function via GABA and categorized as an anesthetic. Etomidate also inhibits adrenal cortisol biosynthesis and mitigates hypercortisolism, as is found in Cushing syndrome.

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BRC1061
Product IDBRC1061
Product classBioreference compound
CAS number77191-36-7
MW246.3
Synonyms
DM 9384; DMMPA; DMPPA; DZL 221; Translon;
Transport conditionsNormal

Nefiracetam

Nefiracetam is cognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Displays potent neuroprotective action in the retinal ischemia-reperfusion model in vivo.

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BRC0246
Product IDBRC0246
Product classBioreference compound
CAS number28311-31-1
MW250.1
Synonyms
(+-)-Baclofen, Baclon, Kemstro, Lioresal Intrathecal,
Transport conditionsNormal

Baclofen hydrochloride

Baclofen is a direct agonist at GABAB receptors.

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BRC0155
Product IDBRC0155
Product classBioreference compound
CAS number84057-84-1
MW256.1
Synonyms
Lamictal, BW-430C
Transport conditionsNormal

Lamotrigine

Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine also acts as a mood stabilizer.

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BRC0464
Product IDBRC0464
Product classBioreference compound
CAS number4815-38-7
MW261.3
Synonyms
Transport conditionsNormal

Ethyl 2-Amino-4-methyl-5-phenylthiophene-3-carboxylate

Glutamate receptors inhibitor.

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BRC0309
Product IDBRC0309
Product classBioreference compound
CAS number155584-74-0
MW262.7
Synonyms
Transport conditionsNormal

VUF 10166

VUF10166 is 5-HT3A receptor antagonist. At 5-HT3AB receptors, it is also an antagonist but is less potent.

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BRC0883
Product IDBRC0883
Product classBioreference compound
CAS number3575-80-2
MW263.4
Synonyms
FG-5111
Transport conditionsNormal

Melperone

Melperone is an atypical antipsychotic. It is 5-HT2A/D2 receptor antagonist (Ki = 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC.

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BRC0421
Product IDBRC0421
Product classBioreference compound
CAS number85650-52-8
MW265.4
Synonyms
Org 3770, 6-Azamianserin, Avanza, Axit, Mirtabene, Mirtaz, Mirtazon, Norset, Promyrtil, Remergil, Remergon, Remeron, Remeron SolTab, Rexer, Zispin
Transport conditionsNormal

Mirtazapine

Mirtazapine, an antidepressant of the piperazinoazepine class, is a tetracyclic compound with an anxiolytic effect. Mirtazapine has fewer ADRs than tricyclic antidepressants and is better tolerated. Selective blockade of specific serotonin receptors by mirtazapine likey minimizes side effects typical of other antidepressants.

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BRC0817
Product IDBRC0817
Product classBioreference compound
CAS number133-16-4
MW270.8
Synonyms
Halestyn; Piocaine;
Transport conditionsNormal

Chloroprocaine

Chloroprocaine is an anesthetic agent indicated for production of local or regional anesthesia. It blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rising of the action potential.

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BRC0941
Product IDBRC0941
Product classBioreference compound
CAS number51-05-8
MW272.8
Synonyms
Novocaine; Vitamin H3; Duracaine; NSC 169497; Nissocaine;
Transport conditionsNormal

Procaine Hydrochloride

Procaine hydrochloride is a local anesthetic. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. It is a sodium channel blocker with a variety of inhibitory effects. Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1.

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BRC0499
Product IDBRC0499
Product classBioreference compound
CAS number965-52-6
MW275.2
Synonyms
RC 27109, RC 30-109, Adral, Antinal, Bacifurane, Diarlidan
Transport conditionsNormal

Nifuroxazide

Nifuroxazide is a broad-spectrum nitrofuran antibiotic used against urinary tract infections and as therapy for acute diarrhea of bacterial origin. Nifuroxazide also inhibits the survival and migration of cancer cells, suppressing tumor growth and metastasis in vivo, at least in part by inhibiting STAT3 (IC50 = 10 µM).

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BRC0348
Product IDBRC0348
Product classBioreference compound
CAS number7416-34-4
MW276.4
Synonyms
Moban
Transport conditionsNormal

Molindone

An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder.

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BRC0784
Product IDBRC0784
Product classBioreference compound
CAS number99614-02-5
MW293.4
Synonyms
GR 38032, Setron, Yatrox
Transport conditionsNormal

Ondansetron

Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors.

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BRC0518
Product IDBRC0518
Product classBioreference compound
CAS number2444-46-4
MW293.4
Synonyms
8-Nordihydrocapsaicin, AH 23491X, NSC 172795, Pseudocapsaicin
Transport conditionsNormal

Nonivamide

Nonivamide is an capsaicinoid. Like capsaicin, it can deter mammals (but not birds or insects) from consuming plants or seeds. Nonivamide is a TRPV1 ion channel agonist. Mammalian TRPV1 is activated by heat and capsaicin, but the avian form is insensitive to capsaicin.

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BRC0428
Product IDBRC0428
Product classBioreference compound
CAS number318-98-9
MW295.8
Synonyms
AY-64043, ICI-45520, NCS-91523, Angilol, Bedranol SR, Cardinol, Ciplar, Deralin, Dociton, Duranol, HEMANGEOL, Inderal, Inderal LA, Indobloc, INNOPRAN, Innopran XL, Prophylux, Sumial
Transport conditionsNormal

Propranolol hydrochloride

Propranolol, the prototype of the beta-adrenergic receptor antagonists, is a competitive, nonselective beta-blocker similar to nadolol without intrinsic sympathomimetic activity. Propanolol is a racemic compound; the l-isomer is responsible for adrenergic blocking activity.

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