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Sodium channel

StructureProduct infoAvailabilityQuantity / Price
BRC0624
Product IDBRC0624
Product classBioreference compound
CAS number106-48-9
MW128.6
Synonyms
NSC-2877;
Transport conditionsNormal

Parachlorophenol

Parachlorophenol is an antibacterial agent. The major mode of action of chlorophenols appears to be the uncoupling of oxidative phosphorylation.

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BRC0249
Product IDBRC0249
Product classBioreference compound
CAS number99-66-1
MW144.2
Synonyms
DPA, n-DPA, Valproate, VPA, Convulex, Depakine, Encorate, Epilim, Valcote, Valparin
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Valproic Acid

Valproic acid is a fatty acid with anticonvulsant properties used in the treatment of epilepsy.

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BRC1079
Product IDBRC1079
Product classBioreference compound
CAS number88-04-0
MW156.6
Synonyms
PCMX; Parametaxylenol; RBA 777;
Transport conditionsNormal

Chloroxylenol

Chloroxylenol is an antiseptic and disinfectant agent used for skin disinfection and cleaning surgical instruments.

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BRC0966
Product IDBRC0966
Product classBioreference compound
CAS number94-09-7
MW165.2
Synonyms
AR01; NSC-41531; NSC-4688;
Transport conditionsNormal

Benzocaine

Benzocaine is a local anesthetic commonly used as a topical pain reliever. It binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions.

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BRC0615
Product IDBRC0615
Product classBioreference compound
CAS number2078-54-8
MW178.3
Synonyms
ICI 35868; Disoprivan; Disoprofol;
Transport conditionsNormal

Propofol

Propofol is a sedative-hypnotic agent for use in the induction and maintenance of anesthesia or sedation. It acts as a potentiator of the GABAA receptor.

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BRC0996
Product IDBRC0996
Product classBioreference compound
CAS number31828-71-4
MW179.3
Synonyms
Kö 1173;
Transport conditionsNormal

Mexiletine

Mexiletine is a local anesthetic, antiarrhythmic agent (Class Ib), structurally similar to lidocaine, but orally active. Use-dependent sodium channel blocker.

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BRC1080
Product IDBRC1080
Product classBioreference compound
CAS number94-25-7
MW193.2
Synonyms
Butylcaine; Hemoride; NSC 128464; Planoform; Scuroform;
Transport conditionsNormal

Butamben

Butamben is a mildly water-soluble, long-duration local anesthetic that is thought to reversibly blocking nerve conduction.

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BRC1064
Product IDBRC1064
Product classBioreference compound
CAS number136-77-6
MW194.3
Synonyms
KOM 14; Mycoderm; NSC 1570; Oxana; Prensol; S.T. 37;
Transport conditionsNormal

Hexylresorcinol

Hexylresorcinol is a substituted dihydroxybenzene. It exhibits antiseptic, anthelmintic and local anaesthetic properties. Hexylresorcinol is an inhibitor of transglutaminase-2 in KB cells. Studies indicate that it reduces DNA oxidative damage in human lymphocytes. Hexylresorcinol is a potent irreversible inhibitor of polyphenol oxidase (PPO) activity.

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BRC0235
Product IDBRC0235
Product classBioreference compound
CAS number68291-97-4
MW212.2
Synonyms
Exceglan, CI-912
Transport conditionsNormal

Zonisamide

Zonisamide is an antiseizure drug chemically classified as a sulfonamide and unrelated to other antiseizure agents.

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BRC0516
Product IDBRC0516
Product classBioreference compound
CAS number180161-14-2
MW216.2
Synonyms
Transport conditionsNormal

6-Fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

Serotonin reuptake inhibitor.

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BRC0181
Product IDBRC0181
Product classBioreference compound
CAS number50-12-4
MW218.3
Synonyms
Mesantoin
Transport conditionsNormal

Mephenytoin

Mephenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy.

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BRC0226
Product IDBRC0226
Product classBioreference compound
CAS number125-33-7
MW218.3
Synonyms
Desoxyphenobarbital, Mysoline, Liskantin, Mizodin, Mylepsinum, Pridona, Primid, Prysoline, Sertan
Transport conditionsNormal
Restrictions Included in DEA controlled list

Primidone

An antiepileptic agent related to the barbiturates; it is partly metabolized to phenobarbital in the body and owes some of its actions to this metabolite. Primidone is a GABA receptor agonist.

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BRC0963
Product IDBRC0963
Product classBioreference compound
CAS number721-50-6
MW220.3
Synonyms
Astra 1512; Astra 1515; Citanest; NSC 40027;
Transport conditionsNormal

Prilocaine

Prilocaine is a local anesthetic that is similar pharmacologically to lidocaine. It binds to the intracellular surface of sodium channels which blocks the subsequent influx of sodium into the cell.

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BRC0052
Product IDBRC0052
Product classBioreference compound
CAS number1744-22-5
MW234.2
Synonyms
Rilutek, RP-54274, PK 26124
Transport conditionsNormal

Riluzole

Psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties. Inhibits glutamate release from presynaptic terminals and increases Na+-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na+ channels and inhibits GABA uptake by striatal synaptosomes; neuroprotective.

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BRC0967
Product IDBRC0967
Product classBioreference compound
CAS number137-58-6
MW234.3
Synonyms
ALGRX-3268; LSM-3165; NSC-40030;
Transport conditionsNormal

Lidocaine

Lidocaine is an anaesthetic agent and class Ib antiarrhythmic agent. It is a selective inverse peripheral histamine H1-receptor agonist. This compound is known to block voltage-gated sodium channels in the inactivated state.

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BRC0926
Product IDBRC0926
Product classBioreference compound
CAS number298-46-4
MW236.3
Synonyms
G-32883; GEIGY 32883; NSC-169864; SPD417; CBZ;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Carbamazepine

Carbamazepine is an anticonvulsant used to control grand mal and psychomotor or focal seizures. It inhibits neuronal voltage-gated Na+ channels. Potentiates GABA-induced Cl- currents in HEK 293 cells expressing the GABAA receptor α1β2γ2 subtype combination. Can induce autophagy by inhibiting inositol synthesis.

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BRC0902
Product IDBRC0902
Product classBioreference compound
CAS number46817-91-8
MW237.3
Synonyms
Transport conditionsNormal

Viloxazine

Viloxazine is a selective noradrenaline reuptake inhibitor with minimal inhibitory effect on the reuptake of 5-HT.

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BRC0217
Product IDBRC0217
Product classBioreference compound
CAS number106308-44-5
MW238.2
Synonyms
Banzel, RUF 331, Xilep, Inovelon
Transport conditionsNormal

Rufinamide

Rufinamide is a triazole derivative antiepileptic that prolongs the inactive state of voltage gated sodium channels thus stabilizing membranes, ultimately blocking the spread of partial seizure activity.

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BRC0694
Product IDBRC0694
Product classBioreference compound
CAS number58-85-5
MW244.3
Synonyms
Meribin, NSC 63865, Rovimix H 2, Vitamin B7, Vitamin H
Transport conditionsNormal

Biotin

Biotin is a growth factor present in minute amounts in every living cell. Plays an indispensable role in numerous naturally occurring carboxylation reactions. Occurs mainly bound to proteins or polypeptides.

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BRC0974
Product IDBRC0974
Product classBioreference compound
CAS number57-41-0
MW252.3
Synonyms
NSC-8722;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Phenytoin

Phenytoin is an antiepileptic drug. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation.

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BRC0824
Product IDBRC0824
Product classBioreference compound
CAS number28721-07-5
MW252.3
Synonyms
GP 47680; KIN-493; SPN-804;
Transport conditionsNormal

Oxcarbazepine

Oxcarbazepine is a sodium channel protein inhibitor. It is structurally a derivative of carbamazepine.

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BRC0054
Product IDBRC0054
Product classBioreference compound
CAS number396-01-0
MW253.3
Synonyms
Dyrenium, Dytac, Triamteren
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Triamterene

Triamterene, a relatively weak, potassium-sparing diuretic and antihypertensive, is used in the management of hypokalemia.

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BRC0155
Product IDBRC0155
Product classBioreference compound
CAS number84057-84-1
MW256.1
Synonyms
Lamictal, BW-430C
Transport conditionsNormal

Lamotrigine

Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine also acts as a mood stabilizer.

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BRC0461
Product IDBRC0461
Product classBioreference compound
CAS number115-46-8
MW267.4
Synonyms
Frenoton, MDL 4829, MER 17, Psychosan, Calmeran, γ-pipradol,
Transport conditionsNormal

Azacyclonol

Azacyclonol is ataractive agent, terfenadine metabolite. Inhibits shock-induced elevation of catecholamine levels in the brain. Shows central depressant effects in vivo. Azacyclonol is a drug used to decrease hallucinations in psychotic individuals.

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BRC0817
Product IDBRC0817
Product classBioreference compound
CAS number133-16-4
MW270.8
Synonyms
Halestyn; Piocaine;
Transport conditionsNormal

Chloroprocaine

Chloroprocaine is an anesthetic agent indicated for production of local or regional anesthesia. It blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rising of the action potential.

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BRC0942
Product IDBRC0942
Product classBioreference compound
CAS number614-39-1
MW271.8
Synonyms
NSC-27461; Biocoryl;
Transport conditionsNormal

Procainamide hydrochloride

Procainamide hydrochloride is a potent blocker of sodium channels. It demonstrates antiarrhythmic effects correlated with blockade of the Na+ channels. Procainamide hydrochloride is DNA methyltransferase inhibitor.

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BRC0941
Product IDBRC0941
Product classBioreference compound
CAS number51-05-8
MW272.8
Synonyms
Novocaine; Vitamin H3; Duracaine; NSC 169497; Nissocaine;
Transport conditionsNormal

Procaine Hydrochloride

Procaine hydrochloride is a local anesthetic. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. It is a sodium channel blocker with a variety of inhibitory effects. Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1.

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BRC0989
Product IDBRC0989
Product classBioreference compound
CAS number15307-86-5
MW296.2
Synonyms
ISV-205;
Transport conditionsNormal

Diclofenac

Diclofenac is a nonsteroidal anti-inflammatory drug with analgesic and antipyretic properties. It inhibits both leukocyte migration and the enzyme cyclooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis.

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BRC0017
Product IDBRC0017
Product classBioreference compound
CAS number17440-83-4
MW302.1
Synonyms
Amipramidin, Amipramidine, Midamor
Transport conditionsNormal

Amiloride hydrochloride dihydrate

Amiloride, an antikaliuretic-diuretic agent, is a pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or diuretic agents. Amiloride works by inhibiting sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys by binding to the amiloride-sensitive sodium channels. This promotes the loss of sodium and water from the body, but without depleting potassium.

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BRC0729
Product IDBRC0729
Product classBioreference compound
CAS number58-54-8
MW303.1
Synonyms
Hydromedin, MK 595, Mingit, NSC 624008, NSC 85791, Otacril, Reomax, Taladren, Uregit
Transport conditionsNormal

Ethacrynic acid

Ethacrynic acid is a compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules.

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BRC0825
Product IDBRC0825
Product classBioreference compound
CAS number56-54-2
MW324.4
Synonyms
CIN-QUIN; Conchinin; Conquinine; Pitayine;
Transport conditionsNormal

Quinidine

Quinidine is an optical isomer of quinine, antiarrhythmic. It dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.

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BRC0381
Product IDBRC0381
Product classBioreference compound
CAS number54-31-9
MW330.7
Synonyms
Frusemide
Transport conditionsNormal

Furosemide

Furosemide is an inhibitor of the Na+/K+/2Cl- (NKCC) cotransporters, NKCC1 and NKCC2 (Ki = ~10 µM for each). It is commonly used as a loop diuretic, blocking NKCC2 action on the apical membrane of the thick ascending limb of Henle epithelial cells. Furosemide also acts as an antagonist of GABAA receptors and as an inhibitor of carbonic anhydrase and organic anion transporter.

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BRC0732
Product IDBRC0732
Product classBioreference compound
CAS number135-09-1
MW331.3
Synonyms
Leodrine, Metflorylthiazidine, NSC 44627, NaClex
Transport conditionsNormal

Hydroflumethiazide

Hydroflumethiazide is a anti-hypertensive and a diuretic. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0736
Product IDBRC0736
Product classBioreference compound
CAS number136434-34-9
MW333.9
Synonyms
LY 248686 HCl, Yentreve
Transport conditionsNormal

Duloxetine hydrochloride

Duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake. The antidepressant and pain inhibitory actions of duloxetine are believed to be related to its potentiation of serotonergic and noradrenergic activity in the CNS.

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BRC0184
Product IDBRC0184
Product classBioreference compound
CAS number97240-79-4
MW339.4
Synonyms
McN-4853, RWJ-17021, Topamax, TPM
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Topiramate

Topiramate is an anticonvulsant indicated in the treatment of epilepsy and migraine. Topiramate enhances GABA-activated chloride channels. In addition, topiramate inhibits excitatory neurotransmission, through actions on kainate and AMPA receptors. There is evidence that topiramate has a specific effect on GluR5 kainate receptors.

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BRC0822
Product IDBRC0822
Product classBioreference compound
CAS number3737-09-5
MW339.5
Synonyms
H 3292, SC 7031, Searle 703
Transport conditionsNormal

Disopyramide

Disopyramide is a class I anti-arrhythmic agent and a sodium channel blocker with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.

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BRC1075
Product IDBRC1075
Product classBioreference compound
CAS number123-03-5
MW340.0
Synonyms
Pionin B 651P; Septolete; TsPKh;
Transport conditionsNormal

Cetylpyridinium Chloride

Cetylpyridinium chloride is a quaternary ammonium with broad-spectrum antiseptic properties. It has been used to study the mechanisms of bacterial and virus inactivation by cationic quaternary ammonium detergents.

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BRC0686
Product IDBRC0686
Product classBioreference compound
CAS number448947-81-7
MW355.3
Synonyms
Transport conditionsNormal

Yoda 1

Yoda 1 is a piezo1 channel activator, sensitizes piezo1 to activation by pressure and slows the inactivation phase of transient currents in human embryonic kidney (HEK) cells.

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BRC1017
Product IDBRC1017
Product classBioreference compound
CAS number316-07-4
MW371.3
Synonyms
Chlorpromazine sulfoxide hydrochloride; NSC 17470;
Transport conditionsNormal

Opromazine Hydrochloride

Opromazine hydrochloride is a derivative of Chlorpromazine, which is a dopamine antagonist of the typical antipsychotic class of medications possessing additional antiadrenergic, antiserotonergic, anticholinergic and antihistaminergic properties.

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BRC0654
Product IDBRC0654
Product classBioreference compound
CAS number34183-22-7
MW377.9
Synonyms
GP 382, GPV 001, Polfenon, SA 79
Transport conditionsNormal

Propafenone hydrochloride

Propafenone Hydrochloride is a sodium channel protein inhibitor. It is a Class 1C antiarrhythmic drug with local anesthetic effects and a direct stabilizing action on myocardial membranes.

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BRC0819
Product IDBRC0819
Product classBioreference compound
CAS number133-67-5
MW380.6
Synonyms
NSC 61560
Transport conditionsNormal

Trichlormethiazide

Trichloromethiazide is a thiazide diuretic, inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0693
Product IDBRC0693
Product classBioreference compound
CAS number1159788-59-6
MW390.9
Synonyms
Haynon, Allergican
Transport conditionsNormal

Chlorpheniramine 2-butenedioate

Chlorpheniramine 2-butenedioate is a histamine H1 antagonist (Kd = 0.4 nM) used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications.

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BRC0448
Product IDBRC0448
Product classBioreference compound
CAS number363628-88-0
MW412.5
Synonyms
Transport conditionsNormal

Org 25543

Org 25543 is selective glycine transporter type 2 inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells.

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BRC0656
Product IDBRC0656
Product classBioreference compound
CAS number1026822-49-0
MW421.8
Synonyms
Transport conditionsNormal

5-(4-chlorophenyl)-N-{[2-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl}pyridine-3-carboxamide

The compound is potent sodium channel protein type blocker (IC50 = 0.003 µM).

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BRC0149
Product IDBRC0149
Product classBioreference compound
CAS number142387-99-3
MW427.5
Synonyms
Ranexa, CVT-303, Latixa, RS 43285-003
Transport conditionsNormal

Ranolazine

Ranolazine has antianginal and anti-ischemic effects that do not depend upon reductions in heart rate or blood pressure. It is the first new anti-anginal developed in over 20 years.

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BRC0532
Product IDBRC0532
Product classBioreference compound
CAS number313254-51-2
MW449.6
Synonyms
PF-0508977
Transport conditionsNormal

ICA 121431

ICA-121431 is a potent, selective inhibitor of the human Nav1.3 and Nav1.1 channels (IC50 = 19 nM and 23 nM respectively) with little or no activity against human Nav1.5 or Nav1.7 channels.

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BRC0913
Product IDBRC0913
Product classBioreference compound
CAS number491864-61-0
MW450.5
Synonyms
Transport conditionsNormal

3-[2-(piperidin-1-yl)ethyl]-2-{3-[3-(trifluoromethyl)phenoxy]phenyl}-1,3-thiazolidin-4-one

The compound is sodium channel blocker (Ki = 90 nM).

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BRC0418
Product IDBRC0418
Product classBioreference compound
CAS number57415-44-8
MW450.8
Synonyms
Almarytm, Apocard, Tambocor
Transport conditionsNormal

Flecainide hydrochloride

Flecainide has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the IC class of antiarrhythmics.

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BRC0660
Product IDBRC0660
Product classBioreference compound
CAS number4682-36-4
MW461.5
Synonyms
BS 5930, Biorphen, Brocadisipal, ORP, WS 2434
Transport conditionsNormal

Orphenadrine citrate

Orphenadrine Citrate is muscarinic receptor antagonist (pKi 7.39), H1 histamine receptor antagonist (pIC50 6.79), a muscle relaxant. It also inhibits the noradrenergic transporter and to block the NMDA receptor ion channel.

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BRC0665
Product IDBRC0665
Product classBioreference compound
CAS number1428327-31-4
MW488.6
Synonyms
Transport conditionsNormal

JNJ-47965567

JNJ-47965567 is potent and selective P2X7 antagonist (pIC50 = 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively). Selective over a panel of 50 other receptors, ion channels and transporters. Brain penetrant.

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