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Calcium channel

StructureProduct infoAvailabilityQuantity / Price
BRC0939
Product IDBRC0939
Product classBioreference compound
CAS number77-67-8
MW141.2
Synonyms
H 940; Mesentol; NSC 64013; PM 671; CN 10395;
Transport conditionsNormal

Ethosuximide

Ethosuximide is an anticonvulsant, used in the treatment of epilepsy. It binds to T-type voltage-sensitive calcium channels.

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BRC0288
Product IDBRC0288
Product classBioreference compound
CAS number127-48-0
MW143.1
Synonyms
Trimethinum, Troxidone, Tridione, Minoale,
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Trimethadione

Trimethadione is an oxazolidinedione anticonvulsant. It is most commonly used to treat epileptic conditions that are resistant to other treatments.

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BRC0935
Product IDBRC0935
Product classBioreference compound
CAS number115-67-3
MW157.2
Synonyms
Isoethadione;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Paramethadione

Paramethadione is an oxazolidinedione anticonvulsant that acts on the central nervous system (CNS) to reduce the number of absence seizures (often seen in epileptics). It reduce T-type calcium currents in thalamic neurons (including thalamic relay neurons).

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BRC0213
Product IDBRC0213
Product classBioreference compound
CAS number95-25-0
MW169.6
Synonyms
Myoflexin, Paraflex, Relaxazone, Remular, Remular-S, Solaxin, Strifon Forte DSC
Transport conditionsNormal

Chlorzoxazone

A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain.

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BRC0274
Product IDBRC0274
Product classBioreference compound
CAS number102767-28-2
MW170.2
Synonyms
UCB 22059, UCB L059, UCB-22059, UCB-L059, SIB-S1, Keppra
Transport conditionsNormal

Levetiracetam

Levetiracetam is an anticonvulsant medication used to treat epilepsy. Levetiracetam may selectively prevent hypersynchronization of epileptiform burst firing and propagation of seizure activity.

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BRC0189
Product IDBRC0189
Product classBioreference compound
CAS number60142-96-3
MW171.2
Synonyms
Gabapentin GR, Neurontin, Aclonium
Transport conditionsNormal

Gabapentin

Gabapentin interacts with cortical neurons at auxillary subunits of voltage-sensitive calcium channels. Gabapentin increases the synaptic concentration of GABA, enhances GABA responses at non-synaptic sites in neuronal tissues, and reduces the release of mono-amine neurotransmitters.

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BRC0466
Product IDBRC0466
Product classBioreference compound
CAS number87-52-5
MW174.2
Synonyms
Donaxine, NSC 16892
Transport conditionsNormal

Gramine

Gramine is a naturally occurring indole alkaloid present in several plant species. Has been found to act as an agonist of the adiponectin receptor 1 (LD50 = 44.6 - 62.9 mg/kg). Gramine is a norepinephrine reuptake inhibitor in synaptic vesicles.

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BRC0823
Product IDBRC0823
Product classBioreference compound
CAS number26675-46-7
MW184.5
Synonyms
R-E 235da1, HCFE 235da2,
Transport conditionsNormal

Isoflurane

Isoflurane is a general inhalation anesthetic. It induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times.

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BRC1080
Product IDBRC1080
Product classBioreference compound
CAS number94-25-7
MW193.2
Synonyms
Butylcaine; Hemoride; NSC 128464; Planoform; Scuroform;
Transport conditionsNormal

Butamben

Butamben is a mildly water-soluble, long-duration local anesthetic that is thought to reversibly blocking nerve conduction.

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BRC0586
Product IDBRC0586
Product classBioreference compound
CAS number151-67-7
MW197.4
Synonyms
Fluothane; NSC 143490; R 123B1;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Halothane

Halothane is inhalation anesthetic. It acts on multiple ion channels, which ultimately depresses nerve conduction, breathing, cardiac contractility.

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BRC0468
Product IDBRC0468
Product classBioreference compound
CAS number40172-65-4
MW200.3
Synonyms
NSC 627
Transport conditionsNormal

SKA 31

SKA 31 is activator of KCa3.1 and KCa2 channels.

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BRC0235
Product IDBRC0235
Product classBioreference compound
CAS number68291-97-4
MW212.2
Synonyms
Exceglan, CI-912
Transport conditionsNormal

Zonisamide

Zonisamide is an antiseizure drug chemically classified as a sulfonamide and unrelated to other antiseizure agents.

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BRC0905
Product IDBRC0905
Product classBioreference compound
CAS number951323-36-7
MW223.1
Synonyms
Transport conditionsNormal

4-Aminophenylguanidine dihydrochloride

The compound has α2-adrenoreceptor antagonist activity.

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BRC1320
Product IDBRC1320
Product classBioreference compound
CAS number2482-00-0
MW228.3
Synonyms
NIH 11035; NSC 56332;
Transport conditionsNormal

Agmatine sulfate

Agmantine is a natural metabolite of the arginine. It binds to human adrenergic receptors and imidazoline (I) receptors. Agmatine acts as an antagonist of the NMDA receptor and nicotinic acetylcholine receptors. It is an antagonist of the serotonin receptor subtype 5-HT3 and blocks ATP-sensitive potassium channels. Agmatine competitively inhibits neuronal, macrophage, endothelial, and inducible nitric oxide synthase and irreversibly inactivates neuronal NOS in the presence of calmodulin.

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BRC0180
Product IDBRC0180
Product classBioreference compound
CAS number364-98-7
MW230.7
Synonyms
Eudemine, Hyperstat, Sch-6783, SRG-95213, Proglycem
Transport conditionsNormal

Diazoxide

Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.

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BRC0518
Product IDBRC0518
Product classBioreference compound
CAS number2444-46-4
MW293.4
Synonyms
8-Nordihydrocapsaicin, AH 23491X, NSC 172795, Pseudocapsaicin
Transport conditionsNormal

Nonivamide

Nonivamide is an capsaicinoid. Like capsaicin, it can deter mammals (but not birds or insects) from consuming plants or seeds. Nonivamide is a TRPV1 ion channel agonist. Mammalian TRPV1 is activated by heat and capsaicin, but the avian form is insensitive to capsaicin.

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BRC0370
Product IDBRC0370
Product classBioreference compound
CAS number58-93-5
MW297.7
Synonyms
HCTZ, NSC 53477, SU 5879
Transport conditionsNormal

Hydrochlorothiazide

A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. Hydrochlorothiazide results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium.

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BRC0522
Product IDBRC0522
Product classBioreference compound
CAS number223500-15-0
MW299.2
Synonyms
Transport conditionsNormal

1-(4-aminophenyl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester

The compound is potent and selective inhibitors of PDE4 for use in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders.

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BRC0151
Product IDBRC0151
Product classBioreference compound
CAS number55268-74-1
MW312.4
Synonyms
Biltricide, Droncit, Cesol, Pyquiton,
Transport conditionsNormal

Praziquantel

Praziquantel is an anthelmintic used in most schistosome and many cestode infestations. Praziquantel effects the permeability of the cell membrane resulting in the contraction of schistosomes. The drug further causes vacuolization and disintegration of the schistosome tegument.

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BRC0232
Product IDBRC0232
Product classBioreference compound
CAS number130-95-0
MW324.4
Synonyms
(-)-Quinine, (8S,9R)-Quinine, Chinin, Jasoquin, QSM, Sulquin
Transport conditionsNormal

Quinine

Quinine is used parenterally to treat life-threatening infections caused by chloroquine-resistant Plasmodium falciparum malaria. Quinine acts as a blood schizonticide although it also has gametocytocidal activity against P. vivax and P. malariae.

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BRC0732
Product IDBRC0732
Product classBioreference compound
CAS number135-09-1
MW331.3
Synonyms
Leodrine, Metflorylthiazidine, NSC 44627, NaClex
Transport conditionsNormal

Hydroflumethiazide

Hydroflumethiazide is a anti-hypertensive and a diuretic. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0346
Product IDBRC0346
Product classBioreference compound
CAS number21829-25-4
MW346.3
Synonyms
Adalat, BAY 1040, Cordipin, Nifediac, Nifedical, Procardia
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Nifedipine

Nifedipine is a dihydropyridine calcium channel blocker widely used as a coronary vasodilator for the treatment of hypertension and angina.

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BRC0338
Product IDBRC0338
Product classBioreference compound
CAS number349085-38-7
MW355.4
Synonyms
TOSLAB 829227
Transport conditionsNormal

HC-030031

HC-030031 is a substituted theophylline derivative. Potent and selective ANKTM1 (TRPA1) inhibitor. It antagonizes allyl isothiocyanate (AITC)- and formalin-evoked calcium influx with IC50 values of 6.2 and 5.3 μM respectively.

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BRC0488
Product IDBRC0488
Product classBioreference compound
CAS number71653-63-9
MW367.3
Synonyms
Foridon, Foridone, PP 1466
Transport conditionsNormal

Riodipine

Riodipine is a calcium channel blocker.

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BRC0417
Product IDBRC0417
Product classBioreference compound
CAS number72509-76-3
MW384.2
Synonyms
CGH-869, Felodur ER, Felogard, Plendil Depottab, Plendil ER, Plendil Retard, Renedil, Splendil, Agon, H 154/82
Transport conditionsNormal

Felodipine

Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction.

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BRC0538
Product IDBRC0538
Product classBioreference compound
CAS number113578-26-0
MW388.4
Synonyms
KR 100
Transport conditionsNormal

m-Nisolpidine

The compound is Ca2+ channel antagonist.

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BRC0059
Product IDBRC0059
Product classBioreference compound
CAS number63675-72-9
MW388.4
Synonyms
Sular, Baymycard, Nisocor, Syscor, BAY K 5552
Transport conditionsNormal

Nisoldipine

Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction.

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BRC0222
Product IDBRC0222
Product classBioreference compound
CAS number364782-34-3
MW393.9
Synonyms
CNC, Mimpara, AMG 073, Sensipar, KRN 1493
Transport conditionsNormal

Cinacalcet hydrochloride

Cinacalcet is a drug that acts as a calcimimetic (i.e. it mimics the action of calcium on tissues).

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BRC0375
Product IDBRC0375
Product classBioreference compound
CAS number83-89-6
MW400.0
Synonyms
Atebrine, Mepacrine
Transport conditionsNormal

Quinacrine

Quinacrine is commonly used as an anti-protozoal agent. It potently prevents misfolding of prion protein (EC50 = 0.3 μM), blocks voltage-dependent sodium channels (IC50 = 3.3 μM), and inhibits aldehyde oxidase (IC50 = 3.3 μM).

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BRC0471
Product IDBRC0471
Product classBioreference compound
CAS number406710-03-0
MW413.5
Synonyms
Transport conditionsNormal

diallyl 4-​(3,​4-​dimethoxyphenyl)​-​2,​6-​dimethyl-​1,​4-​dihydropyridine-​3,​5-​dicarboxylate

Calcium channel blocker.

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BRC0699
Product IDBRC0699
Product classBioreference compound
CAS number903591-53-7
MW413.7
Synonyms
Transport conditionsNormal

N-[5-[2-Chloro-5-(trifluoromethyl)phenyl]-2-pyrazinyl]-2,6-difluorobenzamide

The compound is cytokine and calcium channel inhibitor (IC50 = 2 nM).

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BRC0072
Product IDBRC0072
Product classBioreference compound
CAS number52-01-7
MW416.6
Synonyms
Aldactone, Verospiron, Spiroctan
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Spironolactone

Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM. Spironolactone is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics.

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BRC0443
Product IDBRC0443
Product classBioreference compound
CAS number23887-46-9
MW417.5
Synonyms
NSC291562, Kelinao, Anjieli
Transport conditionsNormal

Cinepazide

Cinepazide is a vasodilator used in China for the treatment of cardiovascular and cerebrovascular diseases, and peripheral vascular diseases. It appears to work by potentiating A2 adenosine receptors.

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BRC0371
Product IDBRC0371
Product classBioreference compound
CAS number66085-59-4
MW418.4
Synonyms
BAY E 9736, Admon, BAY-e 9736, Periplum
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Nimodipine

Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction.

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BRC0813
Product IDBRC0813
Product classBioreference compound
CAS number73-48-3
MW421.4
Synonyms
BE 724-A, FT 81
Transport conditionsNormal

Bendroflumethiazide

Bendroflumethiazide is a thiazide diuretic, inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0149
Product IDBRC0149
Product classBioreference compound
CAS number142387-99-3
MW427.5
Synonyms
Ranexa, CVT-303, Latixa, RS 43285-003
Transport conditionsNormal

Ranolazine

Ranolazine has antianginal and anti-ischemic effects that do not depend upon reductions in heart rate or blood pressure. It is the first new anti-anginal developed in over 20 years.

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BRC0382
Product IDBRC0382
Product classBioreference compound
CAS number985-12-6
MW434.0
Synonyms
Drotin, No-Spa, Taverin
Transport conditionsNormal

Drotaverine hydrochloride

Drotaverine is a spasmolytic agent by inhibiting PDE4 in smooth muscle cells. Drotaverine inhibits phosphodiesterases hydrolysing cAMP, thereby increasing cAMP concentration, decreasing Ca uptake of the cells and changing the distribution of calcium among the cells. It may also have minor allosteric calcium channel blocking properties.

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BRC0376
Product IDBRC0376
Product classBioreference compound
CAS number1042432-58-5
MW438.9
Synonyms
Transport conditionsNormal

CTx-0152960

CTx-0152960, was reported as a new member of the broad spectrum PKI family and developed as a Sepharose-supported kinase capture reagent in the identification of 235 protein kinases from a digest of human breast adenocarcinoma, MDA-MB-231, cells.

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BRC0532
Product IDBRC0532
Product classBioreference compound
CAS number313254-51-2
MW449.6
Synonyms
PF-0508977
Transport conditionsNormal

ICA 121431

ICA-121431 is a potent, selective inhibitor of the human Nav1.3 and Nav1.1 channels (IC50 = 19 nM and 23 nM respectively) with little or no activity against human Nav1.5 or Nav1.7 channels.

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BRC0785
Product IDBRC0785
Product classBioreference compound
CAS number33286-22-5
MW451.0
Synonyms
Adizem XL, Balcor, Cartia XT, Coras
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Diltiazem hydrochloride

Diltiazem hydrochloride is an antihypertensive and cardioprotective agent, calcium channel protein inhibitor. It regulates Ca2+ release from intracellular stores in neutrophils.

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BRC0800
Product IDBRC0800
Product classBioreference compound
CAS number167221-71-8
MW456.3
Synonyms
H-324/38,
Transport conditionsNormal

Clevidipine

Clevidipine is dihydropyridine L-type calcium channel antagonist. It is selective for vascular smooth muscle and is indicated for blood pressure reduction.

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BRC0410
Product IDBRC0410
Product classBioreference compound
CAS number152-11-4
MW491.1
Synonyms
NSC 272366, NSC 657799, Bosoptin, Calan, Covera-HS, Isoptin, Verelan, Verisop, Vermin, Verogalid, Vertab, Vetrimil, Zolvera
Transport conditionsNormal

Verapamil hydrochloride

Verapamil is an L-type calcium channel blocker that also has antiarrythmic activity. The R-enantiomer is more effective at reducing blood pressure compared to the S-enantiomer. However, the S-enantiomer is 20 times more potent than the R-enantiomer at prolonging the PR interval in treating arrhythmias.

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BRC0058
Product IDBRC0058
Product classBioreference compound
CAS number34552-83-5
MW513.5
Synonyms
Imodium, Loperacap, ADL 2-1294
Transport conditionsNormal

Loperamide hydrochloride

Loperamide is a synthetic anti-diarrheal indicated for the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease. Loperamide is an opioid receptor agonist and acts on the mu opioid receptors in the myenteric plexus large intestines; it does not affect the central nervous system like other opioids. It works specifically by decreasing the activity of the myenteric plexus which decreases the motility of the circular and longitudinal smooth muscles of the intestinal wall.

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BRC0411
Product IDBRC0411
Product classBioreference compound
CAS number54527-84-3
MW516.0
Synonyms
RS-69216, Cardene
Transport conditionsNormal

Nicardipine hydrochloride

Nicardipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.

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BRC0662
Product IDBRC0662
Product classBioreference compound
CAS number111470-99-6
MW567.0
Synonyms
AM Arya 5, Alkapress, Regcor, Tensivask, UK 48340-26
Transport conditionsNormal

Amlodipine besylate

Amlodipine besylate is an L-type calcium channel blocker that displays antihypertensive properties. It also displays vasoprotective effects in cardiovascular disease and inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM). Amlodipine besylate Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC50 = 25 μM).

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BRC0049
Product IDBRC0049
Product classBioreference compound
CAS number141625-93-6
MW593.2
Synonyms
UNII-FA36DV299Q, Multaq, SR 33589, SR 33589b
Transport conditionsNormal

Dronedarone hydrochloride

It prolongs the duration of action potential and refractory period in myocardial tissue via inhibition of sodium and potassium channels. Via inhibition of calcium channels and blockage of beta1-adrenergic receptors, a decrease in AV conduction and sinus node function can be observed. Dronedarone can also cause an increase in blood pressure by inhibition of alpha1-adrenergic receptors.

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BRC0314
Product IDBRC0314
Product classBioreference compound
CAS number19774-82-4
MW681.8
Synonyms
Amio-Aqueous IV, Aratac, Arycor, Atlansil, Tachyra
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Amiodarone hydrochloride

Broad-spectrum ion channel blocker; blocks late INa, ICa, IKr and IKs and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca2+ influx in Saccharomyces cerevisiae and causes mitochondrial fragmentation and cell death.

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BRC0035
Product IDBRC0035
Product classBioreference compound
CAS number122647-32-9
MW885.2
Synonyms
Corvert, U-70226E
Transport conditionsNormal

Ibutilide hemifumarate

Ibutilide prolongs the action potential duration and increases both atrial and ventricular refractoriness in vivo, i.e., class III electrophysiologic effects. Voltage clamp studies indicate that ibutilide, at nanomolar concentrations, delays repolarization by activation of a slow, inward current (predominantly sodium), rather than by blocking outward potassium currents, which is the mechanism by which most other class III antiarrhythmics act.

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