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Potassium channel

StructureProduct infoAvailabilityQuantity / Price
BRC1001
Product IDBRC1001
Product classBioreference compound
CAS number504-24-5
MW94.1
Synonyms
EL-970; NSC-15041; N07XX07; Avitrol; Dalfampridine;
Transport conditionsNormal

Dalfampridine

Dalfampridine is a non-selective blocker of voltage-dependent K+-channels. Used to help multiple sclerosis patients walk.

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BRC1069
Product IDBRC1069
Product classBioreference compound
CAS number5908-62-3
MW121.2
Synonyms
1,1-Dioxoisothiazolidine;
Transport conditionsNormal

Propane sultam

Propane sultam is used in the synthesis of orally bioavailable hepatitis B caspid inhibitors as well as in the preparation of cryptochrome inhibitors as antidiabetic agents.

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BRC1021
Product IDBRC1021
Product classBioreference compound
CAS number10045-45-1
MW162.2
Synonyms
1-Ethylbenzimidazolinone
Transport conditionsNormal

1-EBIO

1-EBIO modulates Cl- secretion via direct activation of Ca2+-dependent K+ channel (EC50 = 490 µM in T84 human carcinoma cells).

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BRC0692
Product IDBRC0692
Product classBioreference compound
CAS number76-38-0
MW165.0
Synonyms
DA-759; NSC-110432;
Transport conditionsNormal

Methoxyflurane

Methoxyflurane is an anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability.

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BRC1044
Product IDBRC1044
Product classBioreference compound
CAS number61-80-3
MW168.6
Synonyms
Flexin; McN-485; NSC 24995; Zoxamin;
Transport conditionsNormal

Zoxazolamine

Zoxazolamine is a potent skeletal muscle relaxant that also has uricosuric activity. It is used as a tool for assessing hepatic cytochrome P-450 activity.

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BRC0213
Product IDBRC0213
Product classBioreference compound
CAS number95-25-0
MW169.6
Synonyms
Myoflexin, Paraflex, Relaxazone, Remular, Remular-S, Solaxin, Strifon Forte DSC
Transport conditionsNormal

Chlorzoxazone

A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain.

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BRC0687
Product IDBRC0687
Product classBioreference compound
CAS number13838-16-9
MW184.5
Synonyms
Anesthetic 347; Alyrane;
Transport conditionsNormal

Enflurane

Enflurane is an anesthetic. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. Enflurane acts as a positive allosteric modulator of the GABAA, glycine, and 5-HT3 receptors, and as a negative allosteric modulator of the AMPA, kainate, and NMDA receptors, as well as of nicotinic acetylcholine receptors.

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BRC0823
Product IDBRC0823
Product classBioreference compound
CAS number26675-46-7
MW184.5
Synonyms
R-E 235da1, HCFE 235da2,
Transport conditionsNormal

Isoflurane

Isoflurane is a general inhalation anesthetic. It induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times.

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BRC1080
Product IDBRC1080
Product classBioreference compound
CAS number94-25-7
MW193.2
Synonyms
Butylcaine; Hemoride; NSC 128464; Planoform; Scuroform;
Transport conditionsNormal

Butamben

Butamben is a mildly water-soluble, long-duration local anesthetic that is thought to reversibly blocking nerve conduction.

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BRC0857
Product IDBRC0857
Product classBioreference compound
CAS number28523-86-6
MW200.1
Synonyms
Transport conditionsNormal

Sevoflurane

Sevoflurane is one of the most commonly used volatile anesthetic agents, particularly for outpatient anesthesia, across all ages, as well as in veterinary medicine.

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BRC0468
Product IDBRC0468
Product classBioreference compound
CAS number40172-65-4
MW200.3
Synonyms
NSC 627
Transport conditionsNormal

SKA 31

SKA 31 is activator of KCa3.1 and KCa2 channels.

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BRC0040
Product IDBRC0040
Product classBioreference compound
CAS number38304-91-5
MW209.3
Synonyms
Loniten, Regaine, Minoximen
Transport conditionsNormal

Minoxidil

Minoxidil is an orally effective direct acting peripheral vasodilator that reduces elevated systolic and diastolic blood pressure by decreasing peripheral vascular resistance.

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BRC0905
Product IDBRC0905
Product classBioreference compound
CAS number951323-36-7
MW223.1
Synonyms
Transport conditionsNormal

4-Aminophenylguanidine dihydrochloride

The compound has α2-adrenoreceptor antagonist activity.

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BRC1059
Product IDBRC1059
Product classBioreference compound
CAS number17557-67-4
MW228.3
Synonyms
Transport conditionsNormal

SKA 16

SKA 16 is an anticonvulsant agent.

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BRC0180
Product IDBRC0180
Product classBioreference compound
CAS number364-98-7
MW230.7
Synonyms
Eudemine, Hyperstat, Sch-6783, SRG-95213, Proglycem
Transport conditionsNormal

Diazoxide

Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.

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BRC1049
Product IDBRC1049
Product classBioreference compound
CAS number486-66-8
MW254.2
Synonyms
Daidzin aglycone; FW 635I-1; Isoaurostatin; K 251b; NPI 031E;
Transport conditionsNormal

Daidzein

Daidzein is the aglucon of Daidzin, an inactive analog of Genistein, a tyrosine kinase inhibitor, that allows it to act as a negative control for such experiments. It is a phytoestrogen which may play a role in hormone-produced cancers.

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BRC0258
Product IDBRC0258
Product classBioreference compound
CAS number85371-64-8
MW263.3
Synonyms
Pindac;
Transport conditionsNormal

Pinacidil hydrate

Pinacidil is a cyanoguanidine drug that opens ATP-sensitive potassium channels producing peripheral vasodilatation of arterioles.

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BRC0461
Product IDBRC0461
Product classBioreference compound
CAS number115-46-8
MW267.4
Synonyms
Frenoton, MDL 4829, MER 17, Psychosan, Calmeran, γ-pipradol,
Transport conditionsNormal

Azacyclonol

Azacyclonol is ataractive agent, terfenadine metabolite. Inhibits shock-induced elevation of catecholamine levels in the brain. Shows central depressant effects in vivo. Azacyclonol is a drug used to decrease hallucinations in psychotic individuals.

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BRC0964
Product IDBRC0964
Product classBioreference compound
CAS number64-77-7
MW270.4
Synonyms
NSC-23813; NSC-87833; D 860; U-2043;
Transport conditionsNormal

Tolbutamide

Tolbutamide is a first-generation sulfonylurea antidiabetic agent, used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). Tolbutamide is an inhibitor of sulfonylurea receptor 1 linked to inwardly rectifying potassium channel KIR6.2.

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BRC0942
Product IDBRC0942
Product classBioreference compound
CAS number614-39-1
MW271.8
Synonyms
NSC-27461; Biocoryl;
Transport conditionsNormal

Procainamide hydrochloride

Procainamide hydrochloride is a potent blocker of sodium channels. It demonstrates antiarrhythmic effects correlated with blockade of the Na+ channels. Procainamide hydrochloride is DNA methyltransferase inhibitor.

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BRC0941
Product IDBRC0941
Product classBioreference compound
CAS number51-05-8
MW272.8
Synonyms
Novocaine; Vitamin H3; Duracaine; NSC 169497; Nissocaine;
Transport conditionsNormal

Procaine Hydrochloride

Procaine hydrochloride is a local anesthetic. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. It is a sodium channel blocker with a variety of inhibitory effects. Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1.

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BRC1039
Product IDBRC1039
Product classBioreference compound
CAS number76081-98-6
MW277.3
Synonyms
Transport conditionsNormal

SCH 28080

SCH 28080 is a reversible K+-competitive potent inhibitor of potassium-proton-activated ATPases. It blocks acid secretion through its action against the gastric H+/K+-ATPase.

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BRC0127
Product IDBRC0127
Product classBioreference compound
CAS number83701-22-8
MW289.3
Synonyms
Loniten, Regaine, Minoximen
Transport conditionsNormal

Minoxidil Sulfate

Minoxidil sulfate is a K+ channel agonist and a strong vascular smooth muscle relaxant. Minoxidil sulfate has been used to better understand the blood-brain tumor barrier in syngeneic and allogeneic rat studies and has demonstrated to increase tumor permeability.

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BRC0989
Product IDBRC0989
Product classBioreference compound
CAS number15307-86-5
MW296.2
Synonyms
ISV-205;
Transport conditionsNormal

Diclofenac

Diclofenac is a nonsteroidal anti-inflammatory drug with analgesic and antipyretic properties. It inhibits both leukocyte migration and the enzyme cyclooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis.

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BRC0370
Product IDBRC0370
Product classBioreference compound
CAS number58-93-5
MW297.7
Synonyms
HCTZ, NSC 53477, SU 5879
Transport conditionsNormal

Hydrochlorothiazide

A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. Hydrochlorothiazide results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium.

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BRC0729
Product IDBRC0729
Product classBioreference compound
CAS number58-54-8
MW303.1
Synonyms
Hydromedin, MK 595, Mingit, NSC 624008, NSC 85791, Otacril, Reomax, Taladren, Uregit
Transport conditionsNormal

Ethacrynic acid

Ethacrynic acid is a compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules.

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BRC0892
Product IDBRC0892
Product classBioreference compound
CAS number2863-34-5
MW305.2
Synonyms
Transport conditionsNormal

Bethanidine iodide

Bethanidine iodide is a guanidinium antihypertensive agent that acts by blocking adrenergic transmission.

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BRC0391
Product IDBRC0391
Product classBioreference compound
CAS number1229-29-4
MW315.8
Synonyms
Adapin, Aponal, Curatin, Doxepine, Quitaxon, Sinequan
Transport conditionsNormal

Doxepin hydrochloride

Doxepin, a tricyclic antidepressant of the dibenzoxepin type, is used to treat depression and anxiety and, topically, pruritus associated with eczema. Doxepin has substantial anticholinergic and sedative effects. The E (trans)-isomer is more active as a serotonin reuptake inhibitor while the Z-isomer acts as a sedative.

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BRC0044
Product IDBRC0044
Product classBioreference compound
CAS number113-52-0
MW316.9
Synonyms
Antideprin, Melipramine, Imidobenzyle, Berkomine, Melipramin
Transport conditionsNormal

Imipramine hydrochloride

Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as imipramine and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use.

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BRC0163
Product IDBRC0163
Product classBioreference compound
CAS number105816-04-4
MW317.4
Synonyms
Starlix, Starsis, Fastic, Senaglinide, A-4166
Transport conditionsNormal

Nateglinide

Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release.

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BRC0166
Product IDBRC0166
Product classBioreference compound
CAS number67254-91-5
MW318.1
Synonyms
Meclofenamate, Arquel, Acide meclofenamique, Meclomen
Transport conditionsNormal

Meclofenamate sodium

A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.

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BRC0240
Product IDBRC0240
Product classBioreference compound
CAS number968-81-0
MW324.4
Synonyms
Dimelin, Dymelor, Gamadiabet
Transport conditionsNormal

Acetohexamide

Acetohexamide is an intermediate-acting, first-generation oral sulfonylurea. Sulfonylureas such as acetohexamide bind to an ATP-dependent K+ channel on the cell membrane of pancreatic beta cells.

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BRC0825
Product IDBRC0825
Product classBioreference compound
CAS number56-54-2
MW324.4
Synonyms
CIN-QUIN; Conchinin; Conquinine; Pitayine;
Transport conditionsNormal

Quinidine

Quinidine is an optical isomer of quinine, antiarrhythmic. It dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.

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BRC0232
Product IDBRC0232
Product classBioreference compound
CAS number130-95-0
MW324.4
Synonyms
(-)-Quinine, (8S,9R)-Quinine, Chinin, Jasoquin, QSM, Sulquin
Transport conditionsNormal

Quinine

Quinine is used parenterally to treat life-threatening infections caused by chloroquine-resistant Plasmodium falciparum malaria. Quinine acts as a blood schizonticide although it also has gametocytocidal activity against P. vivax and P. malariae.

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BRC0732
Product IDBRC0732
Product classBioreference compound
CAS number135-09-1
MW331.3
Synonyms
Leodrine, Metflorylthiazidine, NSC 44627, NaClex
Transport conditionsNormal

Hydroflumethiazide

Hydroflumethiazide is a anti-hypertensive and a diuretic. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0363
Product IDBRC0363
Product classBioreference compound
CAS number85721-33-1
MW331.3
Synonyms
Cipro IV, Bay o 9867
Transport conditionsNormal

Ciprofloxacin

Ciprofloxacin is a broad-spectrum antiinfective agent of the fluoroquinolone class. Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive microorganisms. There is no known cross-resistance between ciprofloxacin and other classes of antimicrobials.

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BRC0822
Product IDBRC0822
Product classBioreference compound
CAS number3737-09-5
MW339.5
Synonyms
H 3292, SC 7031, Searle 703
Transport conditionsNormal

Disopyramide

Disopyramide is a class I anti-arrhythmic agent and a sodium channel blocker with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.

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BRC0805
Product IDBRC0805
Product classBioreference compound
CAS number73590-58-6
MW345.4
Synonyms
Omez, OMP, OMZ
Transport conditionsNormal

Omeprazole

Omeprazole is a cell-permeable, selective proton pump inhibitor. It inhibits gastric acid secretion (IC50 = 0.16 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro.

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BRC0838
Product IDBRC0838
Product classBioreference compound
CAS number56296-78-7
MW345.8
Synonyms
Lilly 103472; Lilly 110 140; Prozac;
Transport conditionsNormal

Fluoxetine Hydrochloride

Fluoxetine hydrochloride is the first-in-class antidepressant, selective serotonin-reuptake inhibitor. It displays a selectivity for the serotonin transporter (Kd = 0.81 nM) over the norepinephrine transporter (Kd = 240 nM) and the dopamine transporter (Kd = 3,600 nM). It is used in the clinical treatment of major depression as well as other psychiatric disorders.

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BRC0346
Product IDBRC0346
Product classBioreference compound
CAS number21829-25-4
MW346.3
Synonyms
Adalat, BAY 1040, Cordipin, Nifediac, Nifedical, Procardia
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Nifedipine

Nifedipine is a dihydropyridine calcium channel blocker widely used as a coronary vasodilator for the treatment of hypertension and angina.

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BRC0014
Product IDBRC0014
Product classBioreference compound
CAS number221180-26-3
MW350.2
Synonyms
Ticalopride hydrochloride;
Transport conditionsNormal

Norcisapride hydrochloride

A metabolite of Cisapride, serotonin 4 (5-HT4) receptor agonist.

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BRC0291
Product IDBRC0291
Product classBioreference compound
CAS number69-09-0
MW355.3
Synonyms
Chlorpromanyl, Largactil, Thorazine, J2.794D, NSC-167745, NSC-226514
Transport conditionsNormal

Chlorpromazine

Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia. It antagonizes a range of receptors, including post-synaptic dopamine and serotonin receptors.

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BRC0867
Product IDBRC0867
Product classBioreference compound
CAS number26807-65-8
MW365.8
Synonyms
RHC 2555, S 1520, SE 1520, USV 2555
Transport conditionsNormal

Indapamide

Indapamide is an antihypertensive agent that reduces intracellular calcium levels.

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BRC0141
Product IDBRC0141
Product classBioreference compound
CAS number103577-45-3
MW369.4
Synonyms
A 65006; AG 1749;
Transport conditionsNormal

Lansoprazole

Lansoprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that suppress gastric acid secretion by specific inhibition of the (H+,K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell.

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BRC0654
Product IDBRC0654
Product classBioreference compound
CAS number34183-22-7
MW377.9
Synonyms
GP 382, GPV 001, Polfenon, SA 79
Transport conditionsNormal

Propafenone hydrochloride

Propafenone Hydrochloride is a sodium channel protein inhibitor. It is a Class 1C antiarrhythmic drug with local anesthetic effects and a direct stabilizing action on myocardial membranes.

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BRC0819
Product IDBRC0819
Product classBioreference compound
CAS number133-67-5
MW380.6
Synonyms
NSC 61560
Transport conditionsNormal

Trichlormethiazide

Trichloromethiazide is a thiazide diuretic, inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0774
Product IDBRC0774
Product classBioreference compound
CAS number79794-75-5
MW382.9
Synonyms
SCH-29851,
Transport conditionsNormal

Loratadine

Loratadine is a long acting second generation antihistamine. It is a competitive, specific, and selective antagonist of H1 receptors. Loratadine does not penetrate the CNS effectively and has a low affinity for CNS H1-receptors.

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BRC0383
Product IDBRC0383
Product classBioreference compound
CAS number19216-56-9
MW383.4
Synonyms
Adversuten, CP 12,299-1, NSC 292810, Hypovase, Minipress Xl, Pressin, Vasoflex
Transport conditionsNormal

Prazosin

Prazosin is an adrenergic α, α2B-adrenoceptor and a potent melatonin MT3 receptor antagonist.

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BRC0110
Product IDBRC0110
Product classBioreference compound
CAS number63590-64-7
MW387.4
Synonyms
Hytrin, Flumarc, Fosfomic, Blavin, Abbott 45975
Transport conditionsNormal

Terazosin

Terazosin, classified as a quinazoline, is similar to doxazosin and prazosin. As an α-adrenergic blocking agent, terazosin is used to treat hypertension and BPH. Terazosin produces vasodilation and reduces peripheral resistance but in general has only a slight effect on cardiac output. The antihypertensive effect with chronic dosing is not usually accompanied by reflex tachycardia.

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BRC0853
Product IDBRC0853
Product classBioreference compound
CAS number72956-09-3
MW406.5
Synonyms
BM 14190, SKF 105517
Transport conditionsNormal

Carvedilol

Carvedilol is a nonselective beta-adrenergic blocking agent with alpha1-blocking activity. Indicated for the treatment of hypertension and mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.

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