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BRC0254
Product IDBRC0254
Product classBioreference compound
CAS number142-63-2
MW86.1
Synonyms
Diethylenediamine, Piperazidine, Piperazin, Antepar, Uvilon, Vermidol, Vermizine
Transport conditionsNormal

Piperazine Hexahydrate

Piperazine is a GABA receptor agonist.

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BRC1419
Product IDBRC1419
Product classBioreference compound
CAS number107-97-1
MW89.1
Synonyms
Methylglycine; N-Methylaminoacetic acid; Sarcosin; Sarcosinic acid;
Transport conditionsNormal

Sarcosine

Sarcosine is an endogenous inhibitor of GlyT1 with antipsychotic activity. It potentiates the action of glycine on the NMDA glycine binding site.

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BRC1001
Product IDBRC1001
Product classBioreference compound
CAS number504-24-5
MW94.1
Synonyms
EL-970; NSC-15041; N07XX07; Avitrol; Dalfampridine;
Transport conditionsNormal

Dalfampridine

Dalfampridine is a non-selective blocker of voltage-dependent K+-channels. Used to help multiple sclerosis patients walk.

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BRC1147
Product IDBRC1147
Product classBioreference compound
CAS number22059-21-8
MW101.1
Synonyms
ACC; NSC 98430;
Transport conditionsNormal

ACPC

ACPC is NMDA receptor activity modulator, acts as a partial agonist at the glycine-binding site on NMDA receptors (EC50 = 0.7-0.9 µM) in the presence of low levels (1 µM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 µM) of glutamate.

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BRC1069
Product IDBRC1069
Product classBioreference compound
CAS number5908-62-3
MW121.2
Synonyms
1,1-Dioxoisothiazolidine;
Transport conditionsNormal

Propane sultam

Propane sultam is used in the synthesis of orally bioavailable hepatitis B caspid inhibitors as well as in the preparation of cryptochrome inhibitors as antidiabetic agents.

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BRC0624
Product IDBRC0624
Product classBioreference compound
CAS number106-48-9
MW128.6
Synonyms
NSC-2877;
Transport conditionsNormal

Parachlorophenol

Parachlorophenol is an antibacterial agent. The major mode of action of chlorophenols appears to be the uncoupling of oxidative phosphorylation.

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BRC1245
Product IDBRC1245
Product classBioreference compound
CAS number98-79-3
MW129.1
Synonyms
NSC 143034; Oxoproline; Glutiminic acid; Pidolidone; Pidolic Acid;
Transport conditionsNormal

L-Pyroglutamic acid

L-Pyroglutamic acid is an amino acid that is used in the synthesis of peptides. It is cyclooxygenase inhibitor.

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BRC0928
Product IDBRC0928
Product classBioreference compound
CAS number68506-86-5
MW129.2
Synonyms
CPP-109; MDL 71,754; MDL-71754; RMI-71754; GVG; Sabril™; γ-Vinyl GABA;
Transport conditionsNormal

Vigabatrin

Vigabatrin is a structural analogue of gamma-aminobutyric acid, irreversible inhibitor of 4-aminobutyrate transaminase, the enzyme responsible for the catabolism of gamma-aminobutyric acid.

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BRC1068
Product IDBRC1068
Product classBioreference compound
CAS number3544-24-9
MW136.2
Synonyms
NSC 36962; SR 4294; WD 97-000835;
Transport conditionsNormal

INO-1001

INO-1001 is PARP (poly(ADP-ribose) polymerase) inhibitor (Ki = 1.8 μM), which protects cells from UV-B-induced apoptosis via influence on the cytoskeleton. Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.

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BRC1417
Product IDBRC1417
Product classBioreference compound
CAS number3687-18-1
MW139.2
Synonyms
Alzhemed; Homotaurine; NC 758; NSC 77071; γ-Aminopropylsulfonic acid;
Transport conditionsNormal

Tramiprosate

Tramiprosate is a GABA mimetic that targets soluble amyloid β (Aβ) and maintains Aβ in a non-fibrillar form. Decreases Aβ42-induced neuronal death and inhibit amyloid deposition in vitro. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also, a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo.

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BRC0939
Product IDBRC0939
Product classBioreference compound
CAS number77-67-8
MW141.2
Synonyms
H 940; Mesentol; NSC 64013; PM 671; CN 10395;
Transport conditionsNormal

Ethosuximide

Ethosuximide is an anticonvulsant, used in the treatment of epilepsy. It binds to T-type voltage-sensitive calcium channels.

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BRC1029
Product IDBRC1029
Product classBioreference compound
CAS number59-50-7
MW142.6
Synonyms
NSC 4166; Neopredisan; Parol; Raschit; PCMC;
Transport conditionsNormal

Chlorocresol

Chlorocresol is a chlorinated phenol which is used as an antiseptic and preservative.

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BRC0288
Product IDBRC0288
Product classBioreference compound
CAS number127-48-0
MW143.1
Synonyms
Trimethinum, Troxidone, Tridione, Minoale,
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Trimethadione

Trimethadione is an oxazolidinedione anticonvulsant. It is most commonly used to treat epileptic conditions that are resistant to other treatments.

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BRC0249
Product IDBRC0249
Product classBioreference compound
CAS number99-66-1
MW144.2
Synonyms
DPA, n-DPA, Valproate, VPA, Convulex, Depakine, Encorate, Epilim, Valcote, Valparin
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Valproic Acid

Valproic acid is a fatty acid with anticonvulsant properties used in the treatment of epilepsy.

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BRC0888
Product IDBRC0888
Product classBioreference compound
CAS number4424-20-8
MW147.2
Synonyms
Transport conditionsNormal

5-Azabenzocycloheptene

5-Azabenzocycloheptene is a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.

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BRC0981
Product IDBRC0981
Product classBioreference compound
CAS number103-90-2
MW151.2
Synonyms
NSC-109028; NSC-3991; APAP; Acenol; Paracetamol;
Transport conditionsNormal

Acetaminophen

Acetaminophen is a widely used analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. It is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin synthesis.

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BRC1302
Product IDBRC1302
Product classBioreference compound
CAS number62306-84-7
MW153.6
Synonyms
Transport conditionsNormal

3-methyl-GABA hydrochloride

3-methyl-GABA hydrochloride is activator of GABA aminotransferase.

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BRC1033
Product IDBRC1033
Product classBioreference compound
CAS number64-65-3
MW155.2
Synonyms
Mikedimide; NP 13; NSC 168667; NSC 58187; Zentraleptin;
Transport conditionsNormal

Bemegride

Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning as its chemoreceptor agonism increases mean tidal volume, thereby increasing respiration and the concentration of O2 in blood.

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BRC0815
Product IDBRC0815
Product classBioreference compound
CAS number2216-51-5
MW156.3
Synonyms
NPO-11; NSC-62788;
Transport conditionsNormal

Menthol

Menthol is local anesthetic and counterirritant, and it is widely used to relieve minor throat irritation. Menthol triggers cold-sensitive TRPM8 receptors in the skin neurons in vitro.

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BRC1079
Product IDBRC1079
Product classBioreference compound
CAS number88-04-0
MW156.6
Synonyms
PCMX; Parametaxylenol; RBA 777;
Transport conditionsNormal

Chloroxylenol

Chloroxylenol is an antiseptic and disinfectant agent used for skin disinfection and cleaning surgical instruments.

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BRC0935
Product IDBRC0935
Product classBioreference compound
CAS number115-67-3
MW157.2
Synonyms
Isoethadione;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Paramethadione

Paramethadione is an oxazolidinedione anticonvulsant that acts on the central nervous system (CNS) to reduce the number of absence seizures (often seen in epileptics). It reduce T-type calcium currents in thalamic neurons (including thalamic relay neurons).

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BRC0582
Product IDBRC0582
Product classBioreference compound
CAS number487-19-4
MW158.2
Synonyms
NSC 127943, NSC 407276
Transport conditionsNormal

β-Nicotyrine

β-Nicotyrine is an alkaloid metabolite of nicotine. It binds CYP2A6 (IC50 = 2200nM), which is prominently involved in the metabolism of xenobiotics in the airways.

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BRC0909
Product IDBRC0909
Product classBioreference compound
CAS number182485-36-5
MW161.1
Synonyms
Transport conditionsNormal

TPMPA

TPMPA is GABA receptor antagonist.

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BRC1021
Product IDBRC1021
Product classBioreference compound
CAS number10045-45-1
MW162.2
Synonyms
1-Ethylbenzimidazolinone
Transport conditionsNormal

1-EBIO

1-EBIO modulates Cl- secretion via direct activation of Ca2+-dependent K+ channel (EC50 = 490 µM in T84 human carcinoma cells).

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BRC0818
Product IDBRC0818
Product classBioreference compound
CAS number616-91-1
MW163.2
Synonyms
5052; NSC-111180; RK-0202; NAC; Mercapturic acid;
Transport conditionsNormal

Acetylcysteine

Acetylcysteine (NAC) is an antioxidant and precursor of glutathione that has multiple effects in cells and animals. It is primarily used as a mucolytic agent and in the management of acetaminophen poisoning. It is essentially a prodrug that is converted to cysteine (in the intestine by the enzyme aminoacylase 1) and absorbed in the intestine into the bloodstream. As an antioxidant, NAC scavenges hydrogen peroxide, hydroxyl radical, and hypochlorous acid.

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BRC0969
Product IDBRC0969
Product classBioreference compound
CAS number97-53-0
MW164.2
Synonyms
NSC-209525; NSC-8895; 4-allylguaiacol;
Transport conditionsNormal

Eugenol

Eugenol is an antifungal and antimicrobial agent, TRPV1 receptor agonist. Its exact mechanism of action is unknown, however, it has been shown to interfere with action potential conduction.

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BRC0692
Product IDBRC0692
Product classBioreference compound
CAS number76-38-0
MW165.0
Synonyms
DA-759; NSC-110432;
Transport conditionsNormal

Methoxyflurane

Methoxyflurane is an anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability.

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BRC0966
Product IDBRC0966
Product classBioreference compound
CAS number94-09-7
MW165.2
Synonyms
AR01; NSC-41531; NSC-4688;
Transport conditionsNormal

Benzocaine

Benzocaine is a local anesthetic commonly used as a topical pain reliever. It binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions.

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BRC1066
Product IDBRC1066
Product classBioreference compound
CAS number498-02-2
MW166.2
Synonyms
NSC 209524; NSC 2146;
Transport conditionsNormal

Apocynin

Apocynin is a methoxy-substituted catechol that is commonly used as a selective NADPH-oxidase inhibitor with IC50 of 10 μM. Acts as an antioxidant in endothelial cells and vascular smooth muscle cells.

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BRC1044
Product IDBRC1044
Product classBioreference compound
CAS number61-80-3
MW168.6
Synonyms
Flexin; McN-485; NSC 24995; Zoxamin;
Transport conditionsNormal

Zoxazolamine

Zoxazolamine is a potent skeletal muscle relaxant that also has uricosuric activity. It is used as a tool for assessing hepatic cytochrome P-450 activity.

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BRC0213
Product IDBRC0213
Product classBioreference compound
CAS number95-25-0
MW169.6
Synonyms
Myoflexin, Paraflex, Relaxazone, Remular, Remular-S, Solaxin, Strifon Forte DSC
Transport conditionsNormal

Chlorzoxazone

A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain.

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BRC0274
Product IDBRC0274
Product classBioreference compound
CAS number102767-28-2
MW170.2
Synonyms
UCB 22059, UCB L059, UCB-22059, UCB-L059, SIB-S1, Keppra
Transport conditionsNormal

Levetiracetam

Levetiracetam is an anticonvulsant medication used to treat epilepsy. Levetiracetam may selectively prevent hypersynchronization of epileptiform burst firing and propagation of seizure activity.

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BRC0189
Product IDBRC0189
Product classBioreference compound
CAS number60142-96-3
MW171.2
Synonyms
Gabapentin GR, Neurontin, Aclonium
Transport conditionsNormal

Gabapentin

Gabapentin interacts with cortical neurons at auxillary subunits of voltage-sensitive calcium channels. Gabapentin increases the synaptic concentration of GABA, enhances GABA responses at non-synaptic sites in neuronal tissues, and reduces the release of mono-amine neurotransmitters.

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BRC0466
Product IDBRC0466
Product classBioreference compound
CAS number87-52-5
MW174.2
Synonyms
Donaxine, NSC 16892
Transport conditionsNormal

Gramine

Gramine is a naturally occurring indole alkaloid present in several plant species. Has been found to act as an agonist of the adiponectin receptor 1 (LD50 = 44.6 - 62.9 mg/kg). Gramine is a norepinephrine reuptake inhibitor in synaptic vesicles.

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BRC0615
Product IDBRC0615
Product classBioreference compound
CAS number2078-54-8
MW178.3
Synonyms
ICI 35868; Disoprivan; Disoprofol;
Transport conditionsNormal

Propofol

Propofol is a sedative-hypnotic agent for use in the induction and maintenance of anesthesia or sedation. It acts as a potentiator of the GABAA receptor.

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BRC0996
Product IDBRC0996
Product classBioreference compound
CAS number31828-71-4
MW179.3
Synonyms
Kö 1173;
Transport conditionsNormal

Mexiletine

Mexiletine is a local anesthetic, antiarrhythmic agent (Class Ib), structurally similar to lidocaine, but orally active. Use-dependent sodium channel blocker.

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BRC0687
Product IDBRC0687
Product classBioreference compound
CAS number13838-16-9
MW184.5
Synonyms
Anesthetic 347; Alyrane;
Transport conditionsNormal

Enflurane

Enflurane is an anesthetic. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. Enflurane acts as a positive allosteric modulator of the GABAA, glycine, and 5-HT3 receptors, and as a negative allosteric modulator of the AMPA, kainate, and NMDA receptors, as well as of nicotinic acetylcholine receptors.

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BRC0823
Product IDBRC0823
Product classBioreference compound
CAS number26675-46-7
MW184.5
Synonyms
R-E 235da1, HCFE 235da2,
Transport conditionsNormal

Isoflurane

Isoflurane is a general inhalation anesthetic. It induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times.

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BRC0260
Product IDBRC0260
Product classBioreference compound
CAS number665-66-7
MW187.7
Synonyms
Aminoadamantane, Viregyt, Virosol, PK-Merz, Symadine, Symmetrel
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Amantadine hydrochloride

Amantadine is an antiviral drug which also acts as an antiparkinson agent, for which it is usually combined with L-DOPA when L-DOPA responses decline (probably due to tolerance).

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BRC0460
Product IDBRC0460
Product classBioreference compound
CAS number51314-51-3
MW189.3
Synonyms
Transport conditionsNormal

NSC 139486

Transient receptor potential canonical (TRPC) channel inhibitor.

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BRC0023
Product IDBRC0023
Product classBioreference compound
CAS number62-31-7
MW189.6
Synonyms
3-Hydroxytyramine, Deoxyepinephrine, Oxytyramine, Intropin, Revimine
Transport conditionsNormal

Dopamine hydrochloride

Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility.

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BRC1080
Product IDBRC1080
Product classBioreference compound
CAS number94-25-7
MW193.2
Synonyms
Butylcaine; Hemoride; NSC 128464; Planoform; Scuroform;
Transport conditionsNormal

Butamben

Butamben is a mildly water-soluble, long-duration local anesthetic that is thought to reversibly blocking nerve conduction.

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BRC0295
Product IDBRC0295
Product classBioreference compound
CAS number58-08-2
MW194.2
Synonyms
Methyltheobromine, NSC 5036
Transport conditionsNormal

Caffeine

Central nervous system stimulant. Antagonist at A1 and A2A adenosine receptors and inhibitor of cyclic nucleotide phosphodiesterases. Mobilizes calcium from intracellular stores and inhibits benzodiazepine binding to GABA receptors.

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BRC1077
Product IDBRC1077
Product classBioreference compound
CAS number94-26-8
MW194.2
Synonyms
NSC 13164; NSC 8475; Nipabutyl; SPF;
Transport conditionsNormal

Butylparaben

Butylparaben is an antifungal preservative in cosmetic products.

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BRC1064
Product IDBRC1064
Product classBioreference compound
CAS number136-77-6
MW194.3
Synonyms
KOM 14; Mycoderm; NSC 1570; Oxana; Prensol; S.T. 37;
Transport conditionsNormal

Hexylresorcinol

Hexylresorcinol is a substituted dihydroxybenzene. It exhibits antiseptic, anthelmintic and local anaesthetic properties. Hexylresorcinol is an inhibitor of transglutaminase-2 in KB cells. Studies indicate that it reduces DNA oxidative damage in human lymphocytes. Hexylresorcinol is a potent irreversible inhibitor of polyphenol oxidase (PPO) activity.

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BRC0586
Product IDBRC0586
Product classBioreference compound
CAS number151-67-7
MW197.4
Synonyms
Fluothane; NSC 143490; R 123B1;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Halothane

Halothane is inhalation anesthetic. It acts on multiple ion channels, which ultimately depresses nerve conduction, breathing, cardiac contractility.

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BRC0595
Product IDBRC0595
Product classBioreference compound
CAS number67730-11-4
MW198.2
Synonyms
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Glu-P1

Glu-P1 is an mutagenic compound.

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BRC1074
Product IDBRC1074
Product classBioreference compound
CAS number153322-05-5
MW198.3
Synonyms
ARL 15896; FPL 15896; AR-R15896; AZD6765;
Transport conditionsNormal

Lanicemine

Lanicemine is a non-selective, voltage-dependent NMDA channel blocker (IC50 = 4-7 µM). It has been used in trials studying the treatment and basic science of Depression, Major Depressive Disorder, and Treatment-Resistant Major Depressive Disorder.

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BRC0550
Product IDBRC0550
Product classBioreference compound
CAS number19772-76-0
MW199.2
Synonyms
DL-Willardiine
Transport conditionsNormal

(±)-Willardiine

(±)-Willardiine is a selective inhibitor of specific binding of [3H]AMPA to Ionotropic glutamate receptor AMPA (IC50 = 1800 nM).

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BRC0857
Product IDBRC0857
Product classBioreference compound
CAS number28523-86-6
MW200.1
Synonyms
Transport conditionsNormal

Sevoflurane

Sevoflurane is one of the most commonly used volatile anesthetic agents, particularly for outpatient anesthesia, across all ages, as well as in veterinary medicine.

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