Non-classical benzene bioisosteres
Bioisosteric replacement of various groups is an important technique in the Medicinal Chemist’s toolbox. Replacing a phenyl or benzene ring with a non-classical ring system, rather than just a spacer, can improve physiochemical properties such as passive permeability and aqueous solubility. To see examples see below:
Search returned 477 hits.
| Structure | Product info | Availability | Quantity / Price |
|---|---|---|---|
Catalog ID
EN300-345564 Product class
Building Block
Namebicyclo[1.1.1]pentane-1-carbaldehyde ACD numberMFCD24393552 CAS number117633-03-1 Formula MW96.1 CLogP0.444 Storage conditions-10 Transport conditionsIce pack See details |  Now available as 80.0% pureGlobal stock:1.4 g | ||
Catalog ID
EN300-1608565 Product class
Building Block
Name{bicyclo[1.1.1]pentan-1-yl}methanol ACD numberMFCD28040494 CAS number22287-32-7 Formula MW98.1 CLogP1.043 Storage conditions+4 Transport conditionsNormal See details | Purity: 95.0%Global stock:> 10 g EU Rush delivery : (2 business days) 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g, 1x5 gUSA Rush delivery(2 business days) available in New Jersey stock : 3x0.05 g, 2x0.1 g, 2x0.25 g, 2x0.5 g, 1x1 g, 1x2.5 g, 1x5 g | ||
Catalog ID
EN300-23294351 Product class
Building Block
Name3-methylbicyclo[1.1.1]pentan-1-ol ACD numberMFCD31537338 CAS number2091012-43-8 Formula MW98.1 CLogP0.423 Storage conditions+4 Transport conditionsIce pack See details | Purity: 95.0%Global stock:> 10 g EU Rush delivery : (2 business days) 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 gUSA Rush delivery(2 business days) available in New Jersey stock : 2x0.05 g, 2x0.1 g, 2x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g | ||
Catalog ID
EN300-6763405 Product class
Building Block
Namebicyclo[1.1.1]pentane-1-thiol ACD numberMFCD31915505 CAS number754149-00-3 Formula MW100.2 CLogP1.314 Storage conditions+4 Transport conditionsIce pack See details | Purity: 95.0%Global stock:> 10 g | ||
Catalog ID
EN300-1267276 Product class
Building Block
Name1-{bicyclo[1.1.1]pentan-1-yl}ethan-1-one ACD numberMFCD24691484 CAS number137335-61-6 Formula MW110.2 CLogP0.46 Storage conditions+4 Transport conditionsIce pack See details | Purity: 95.0%Global stock:> 10 g USA Rush delivery(2 business days) available in New Jersey stock : 2x0.25 g, 2x0.5 g, 1x1 g, 1x2.5 g | ||
Catalog ID
EN300-83811 Product class
Building Block
Namebicyclo[1.1.1]pentane-1-carboxylic acid ACD numberMFCD19228106 CAS number22287-28-1 Formula MW112.1 CLogP0.474 Storage conditions+4 Transport conditionsNormal See details | Purity: 95.0%Global stock:> 10 g EU Rush delivery : (2 business days) 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g, 1x5 gUSA Rush delivery(2 business days) available in New Jersey stock : 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g, 1x5 g | ||
Catalog ID
EN300-27152160 Product class
Building Block
Name3-ethylbicyclo[1.1.1]pentan-1-ol ACD numberMFCD33549847 CAS number2639409-42-8 Formula MW112.2 CLogP Storage conditions+4 Transport conditionsIce pack See details | Purity: 95.0%Global stock:> 10 g EU Rush delivery : (2 business days) 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 gUSA Rush delivery(2 business days) available in New Jersey stock : 3x0.05 g, 3x0.1 g, 3x0.25 g, 3x0.5 g, 2x1 g, 1x2.5 g, 1x5 g | ||
Catalog ID
EN300-329105 Product class
Building Block
Name{2-oxabicyclo[2.1.1]hexan-1-yl}methanol ACD numberMFCD30486978 CAS number2060007-65-8 Formula MW114.1 CLogP-0.537 Storage conditions+4 Transport conditionsNormal See details | Purity: 95.0%Global stock:> 10 g EU Rush delivery : (2 business days) 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g, 1x5 gUSA Rush delivery(2 business days) available in New Jersey stock : 2x0.05 g, 2x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g | ||
Catalog ID
EN300-1703642 Product class
Building Block
Name{3-fluorobicyclo[1.1.1]pentan-1-yl}methanol ACD numberMFCD29037345 CAS number262852-01-7 Formula MW116.1 CLogP0.436 Storage conditions+4 Transport conditionsNormal See details | Purity: 95.0%Global stock:> 10 g EU Rush delivery : (2 business days) 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g, 1x5 gUSA Rush delivery(2 business days) available in New Jersey stock : 2x0.05 g, 2x0.1 g, 1x0.25 g, 1x0.5 g | ||
Catalog ID
EN300-295395 Product class
Building Block
Namebicyclo[1.1.1]pentan-1-amine hydrochloride ACD numberMFCD19204065 CAS number22287-35-0 Formula MW119.6 CLogP0.004 Storage conditions+4 Transport conditionsNormal See details | Purity: 95.0%Global stock:> 10 g EU Rush delivery : (2 business days) 2x0.25 g, 2x0.5 g, 2x1 g, 2x2.5 g, 1x5 g, 1x10 gUSA Rush delivery(2 business days) available in New Jersey stock : 3x0.25 g, 2x0.5 g, 1x1 g, 1x2.5 g, 1x5 g, 1x10 g | ||
Catalog ID
EN300-173156 Product class
Building Block
Name2-{bicyclo[1.1.1]pentan-1-yl}acetic acid ACD numberMFCD19229645 CAS number131515-31-6 Formula MW126.2 CLogP1.613 Storage conditions+4 Transport conditionsIce pack See details | Purity: 95.0%Global stock:> 10 g EU Rush delivery : (2 business days) 2x0.05 g, 2x0.1 g, 2x0.25 g, 2x0.5 g, 1x1 g, 1x2.5 g, 1x5 gUSA Rush delivery(2 business days) available in New Jersey stock : 2x0.05 g, 2x0.1 g, 2x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g | ||
Catalog ID
EN300-6218213 Product class
Building Block
Name[3-(aminomethyl)bicyclo[1.1.1]pentan-1-yl]methanol ACD numberMFCD27664952 CAS number1823918-02-0 Formula MW127.2 CLogP-0.325 Storage conditions+4 Transport conditionsNormal See details | Purity: 95.0%Global stock:7.9 g EU Rush delivery : (2 business days) 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 gUSA Rush delivery(2 business days) available in New Jersey stock : 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g | ||
Catalog ID
EN300-7433125 Product class
Building Block
Namerac-(1R,3R,4S)-3-hydroxybicyclo[2.1.0]pentane-1-carboxylic acid ACD number CAS number2410594-78-2 Formula MW128.1 CLogP-0.529 Storage conditions-10 Transport conditionsIce pack See details | Purity: 95.0%Global stock:> 10 g USA Rush delivery(2 business days) available in New Jersey stock : 2x0.05 g, 2x0.1 g, 2x0.25 g, 2x0.5 g, 1x1 g | ||
Catalog ID
EN300-1604607 Product class
Building Block
Name2-oxabicyclo[2.1.1]hexane-4-carboxylic acid ACD numberMFCD28650664 CAS number1784145-36-3 Formula MW128.1 CLogP-0.294 Storage conditions+4 Transport conditionsNormal See details | Purity: 95.0%Global stock:> 10 g EU Rush delivery : (2 business days) 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g, 1x5 gUSA Rush delivery(2 business days) available in New Jersey stock : 2x0.25 g, 2x0.5 g, 1x1 g, 1x2.5 g, 1x5 g | ||
Catalog ID
EN300-6729668 Product class
Building Block
Name1-ethynylcubane ACD numberMFCD28955445 CAS number163332-93-2 Formula MW128.2 CLogP1.986 Storage conditions+4 Transport conditionsNormal See details | Purity: 95.0%Global stock:2.2 g EU Rush delivery : (2 business days) 1x0.25 g, 1x0.5 g, 1x1 gUSA Rush delivery(2 business days) available in New Jersey stock : 1x0.25 g, 1x0.5 g | ||
Catalog ID
EN300-6734455 Product class
Building Block
Name{4-amino-2-oxabicyclo[2.1.1]hexan-1-yl}methanol ACD numberMFCD31705632 CAS number2170372-31-1 Formula MW129.2 CLogP-1.274 Storage conditions+4 Transport conditionsNormal See details | Purity: 95.0%Global stock:> 10 g EU Rush delivery : (2 business days) 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g, 1x5 gUSA Rush delivery(2 business days) available in New Jersey stock : 3x0.25 g, 3x0.5 g, 3x1 g, 2x2.5 g, 2x5 g | ||
Catalog ID
EN300-39851208 Product class
Building Block
Name3-(2H3)methylbicyclo[1.1.1]pentane-1-carboxylic acid ACD number CAS number2901095-35-8 Formula MW129.2 CLogP Storage conditions+4 Transport conditionsNormal See details | Purity: 95.0%Global stock:8.5 g USA Rush delivery(2 business days) available in New Jersey stock : 2x0.05 g, 2x0.1 g, 2x0.25 g, 2x0.5 g, 1x1 g | ||
Catalog ID
EN300-253473 Product class
Building Block
Name3-fluorobicyclo[1.1.1]pentane-1-carboxylic acid ACD numberMFCD19228680 CAS number146038-53-1 Formula MW130.1 CLogP0.317 Storage conditions-10 Transport conditionsIce pack See details | Purity: 95.0%Global stock:> 10 g EU Rush delivery : (2 business days) 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g, 1x5 gUSA Rush delivery(2 business days) available in New Jersey stock : 2x0.25 g, 2x0.5 g, 1x1 g | ||
Catalog ID
EN300-6760694 Product class
Building Block
Name1-(chloromethyl)-3-methylbicyclo[1.1.1]pentane ACD numberMFCD35074736 CAS number2287287-24-3 Formula MW130.6 CLogP3.262 Storage conditions+4 Transport conditionsNormal See details | Purity: 95.0%Global stock:> 10 g USA Rush delivery(2 business days) available in New Jersey stock : 2x0.05 g, 2x0.1 g, 2x0.25 g, 2x0.5 g, 2x1 g, 1x2.5 g | ||
Catalog ID
EN300-27695481 Product class
Building Block
Name3-(difluoromethyl)bicyclo[1.1.1]pentan-1-ol ACD numberMFCD34475499 CAS number2694728-58-8 Formula MW134.1 CLogP Storage conditions+4 Transport conditionsIce pack See details | Purity: 95.0%Global stock:1.9 g USA Rush delivery(2 business days) available in New Jersey stock : 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g |
