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Diamine scaffolds


Diamine scaffolds are particularly useful templates for lead generation and lead optimization. Incorporation of such scaffolds can impart restricted confirmations with enhanced desirable physiochemical profile of the resulting products. Moreover these scaffolds have a proven track record in target class areas such as GCPRs. At the EnamineStore you will find readily available examples of diamine scaffold encompassing aliphatic ring systems including spiro, bridged and fused examples with appropriate ‘protection’ of one of the amine groups. Take a look below for representative examples.
StructureProduct infoAvailabilityQuantity / Price
Catalog IDEN300-204916
Product class Building Block
Name2,2-dimethyl-1,4-diazepane
ACD numberMFCD19221013
CAS number105627-82-5
Formula
MW128.2
CLogP0.113
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 5 g 1x0.25, 1x0.5, 1x1, 1x2.5, 1x5
Catalog IDEN300-366698
Product class Building Block
Name4H,5H,6H,7H-pyrazolo[1,5-a]pyrazin-2-amine
ACD numberMFCD28654772
CAS number1785544-01-5
Formula
MW138.2
CLogP-1.205
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-136719
Product class Building Block
Name2,8-diazaspiro[4.5]decane
ACD numberMFCD16877059
CAS number176-67-0
Formula
MW140.2
CLogP-0.052
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-101297
Product class Building Block
NameN,N-dimethylpiperazine-2-carboxamide
ACD numberMFCD18268340
CAS number85817-21-6
Formula
MW157.2
CLogP-0.881
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.25, 1x0.5, 1x1EU Rush delivery(1 g)(2 business days)
1x0.25, 1x0.5, 1x1
Catalog IDEN300-117558
Product class Building Block
Nametert-butyl N-(2-aminocyclobutyl)carbamate, Mixture of diastereomers
ACD numberMFCD20723359
CAS number1378864-01-7
Formula
MW186.3
CLogP0.871
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:4.2 g(5 business days)  
Catalog IDEN300-27068
Product class Building Block
Nametert-butyl N-(3-aminocyclobutyl)carbamate, Mixture of diastereomers
ACD numberMFCD12755997
CAS number1090904-48-5
Formula
MW186.3
CLogP1.337
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   EU Rush delivery(1 g)(2 business days)
1x0.25, 1x0.5, 1x1
Catalog IDEN300-53089
Product class Building Block
Namerac-tert-butyl N-[(1r,3r)-3-aminocyclobutyl]carbamate, trans
ACD numberMFCD09040641
CAS number871014-19-6
Formula
MW186.3
CLogP1.337
Storage conditions-10
Transport conditionsIce pack
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 1 g 1x0.25, 1x0.5, 1x1EU Rush delivery(1 g)(2 business days)
1x0.25, 1x0.5, 1x1
Catalog IDEN300-140744
Product class Building Block
Nametert-butyl 3-amino-3-methylazetidine-1-carboxylate
ACD numberMFCD12408556
CAS number1158758-77-0
Formula
MW186.3
CLogP1.887
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 2 g 1x0.25, 1x0.5, 2x1
Catalog IDEN300-55580
Product class Building Block
Namerac-tert-butyl N-[(1s,3s)-3-aminocyclobutyl]carbamate, cis
ACD numberMFCD11099896
CAS number1212395-34-0
Formula
MW186.3
CLogP1.337
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   EU Rush delivery(1 g)(2 business days)
1x0.25, 1x0.5, 1x1
Catalog IDEN300-101454
Product class Building Block
Nametert-butyl 3-(aminomethyl)azetidine-1-carboxylate
ACD numberMFCD01861762
CAS number325775-44-8
Formula
MW186.3
CLogP0.906
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-399915
Product class Building Block
Nametert-butyl (4R)-4-amino-1,2-oxazolidine-2-carboxylate
ACD numberMFCD31381394
CAS number2089610-73-9
Formula
MW188.2
CLogP1.229
Storage conditions+4
Transport conditionsIce pack
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-378067
Product class Building Block
Name1-[(3aR,6aS)-octahydropyrrolo[3,4-c]pyrrol-2-yl]ethan-1-one hydrochloride, cis
ACD numberMFCD30750058
CAS number2126144-11-2
Formula
MW190.7
CLogP-1.05
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 5 g 1x0.25, 1x0.5, 1x1, 1x2.5, 1x5
Catalog IDEN300-89740
Product class Building Block
Nametert-butyl 2,5-diazabicyclo[4.1.0]heptane-2-carboxylate
ACD numberMFCD17480504
CAS number1228675-18-0
Formula
MW198.3
CLogP1.78
Storage conditions-10
Transport conditionsIce pack
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-153078
Product class Building Block
Nametert-butyl (3-aminobicyclo[1.1.1]pentan-1-yl)carbamate
ACD numberMFCD27987307
CAS number1638767-25-5
Formula
MW198.3
CLogP1.758
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-343327
Product class Building Block
Nametert-butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
ACD numberMFCD01569250
CAS number113451-59-5
Formula
MW198.3
CLogP1.692
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-87141
Product class Building Block
Nametert-butyl (1R,5S,6R)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate, endo
ACD numberMFCD09832898
CAS number273206-92-1
Formula
MW198.3
CLogP1.354
Storage conditions+4
Transport conditionsIce pack
Purity: 95%Global stock:> 10 g(5 business days)   EU Rush delivery(1 g)(2 business days)
1x0.25, 1x0.5, 1x1
Catalog IDEN300-268774
Product class Building Block
Namerac-tert-butyl N-[(1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-yl]carbamate, endo
ACD numberMFCD12198677
CAS number134575-17-0
Formula
MW198.3
CLogP1.185
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-179432
Product class Building Block
Nametert-butyl N-(4-methylpyrrolidin-3-yl)carbamate
ACD numberMFCD08461138
CAS number107610-92-4
Formula
MW200.3
CLogP1.47
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   EU Rush delivery(1 g)(2 business days)
1x0.25, 1x0.5, 1x1
Catalog IDEN300-307325
Product class Building Block
Namerac-tert-butyl (3R,4S)-3-amino-4-hydroxypyrrolidine-1-carboxylate, cis
ACD numberMFCD14582421
CAS number138026-97-8
Formula
MW202.3
CLogP0.69
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   EU Rush delivery(1 g)(2 business days)
1x0.25, 1x0.5, 1x1
Catalog IDEN300-300052
Product class Building Block
Name6-benzyl-2,6-diazaspiro[3.4]octane
ACD numberMFCD08234736
CAS number135380-28-8
Formula
MW202.3
CLogP1.814
Storage conditions+4
Transport conditionsIce pack
Purity: 95%Global stock:1.1 g(5 business days)  
Catalog IDEN300-64022
Product class Building Block
Nametert-butyl N-[(1S,2S)-2-aminocyclopropyl]carbamate hydrochloride
ACD numberMFCD09878306
CAS number1332634-89-5
Formula
MW208.7
CLogP1.438
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-257954
Product class Building Block
Namerac-tert-butyl (1R,6S)-3,8-diazabicyclo[4.2.0]octane-3-carboxylate, cis
ACD numberMFCD17016497
CAS number370881-06-4
Formula
MW212.3
CLogP1.321
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 2 g 1x0.25, 1x0.5, 2x1
Catalog IDEN300-128722
Product class Building Block
Nametert-butyl N-{2-azabicyclo[2.1.1]hexan-1-ylmethyl}carbamate
ACD numberMFCD17017104
CAS number1250997-46-6
Formula
MW212.3
CLogP1.325
Storage conditionsRT
Transport conditionsNormal
Now available as 90% pureGlobal stock:> 10 g(5 business days)  
Catalog IDEN300-255875
Product class Building Block
Nametert-butyl N-{5-azaspiro[2.4]heptan-7-yl}carbamate
ACD numberMFCD11519121
CAS number152513-88-7
Formula
MW212.3
CLogP1.799
Storage conditions+4
Transport conditionsIce pack
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-1074346
Product class Building Block
Namerac-tert-butyl N-{[(1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-yl]methyl}carbamate
ACD numberMFCD14581078
CAS number134575-12-5
Formula
MW212.3
CLogP0.506
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.25, 1x0.5, 1x1EU Rush delivery(5 g)(2 business days)
1x0.25, 1x0.5, 1x1, 1x2.5, 1x5
Catalog IDEN300-384543
Product class Building Block
Namerac-tert-butyl (1R,6R)-6-amino-2-azabicyclo[4.1.0]heptane-2-carboxylate
ACD numberMFCD30742622
CAS number2137676-21-0
Formula
MW212.3
CLogP1.669
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:2.1 g(5 business days)  
Catalog IDEN300-378608
Product class Building Block
Nametert-butyl 3-(1-aminocyclopropyl)azetidine-1-carboxylate
ACD numberMFCD22566184
CAS number1352012-69-1
Formula
MW212.3
CLogP0.636
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-27794
Product class Building Block
Nametert-butyl 5-amino-2-azabicyclo[2.2.1]heptane-2-carboxylate
ACD number
CAS number207405-62-7
Formula
MW212.3
CLogP1.16
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:2.7 g(5 business days)   EU Rush delivery(1 g)(2 business days)
1x0.25, 1x0.5, 1x1
Catalog IDEN300-56100
Product class Building Block
Nametert-butyl 3,7-diazabicyclo[4.2.0]octane-3-carboxylate
ACD numberMFCD08234914
CAS number885271-67-0
Formula
MW212.3
CLogP1.507
Storage conditions-10
Transport conditionsIce pack
USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-128723
Product class Building Block
Nametert-butyl 1-(aminomethyl)-2-azabicyclo[2.1.1]hexane-2-carboxylate
ACD numberMFCD17017103
CAS number1250997-62-6
Formula
MW212.3
CLogP1.499
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 5.1 g 1x0.002, 1x0.005, 1x0.01, 1x0.02, 1x0.025, 1x0.05, 1x0.1, 1x0.25, 1x0.5, 1x1, 1x2.5, 1x5
Catalog IDEN300-100907
Product class Building Block
Namerac-tert-butyl (3aR,6aS)-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate, cis
ACD numberMFCD04116224
CAS number250275-15-1
Formula
MW212.3
CLogP1.507
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-366886
Product class Building Block
Nametert-butyl N-({3-aminobicyclo[1.1.1]pentan-1-yl}methyl)carbamate
ACD numberMFCD27987306
CAS number1630906-49-8
Formula
MW212.3
CLogP0.379
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.002, 1x0.005, 1x0.01, 1x0.02, 1x0.025, 1x0.05, 1x0.1, 1x0.25, 1x0.5, 1x1
Catalog IDEN300-154247
Product class Building Block
Nametert-butyl 4-aminoazepane-1-carboxylate
ACD numberMFCD07371372
CAS number196613-57-7
Formula
MW214.3
CLogP1.44
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 2 g 1x0.25, 1x0.5, 2x1
Catalog IDEN300-91699
Product class Building Block
Nametert-butyl 3,3-dimethylpiperazine-1-carboxylate
ACD numberMFCD07371651
CAS number259808-67-8
Formula
MW214.3
CLogP2.603
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 5 g 1x0.25, 1x0.5, 1x1, 1x2.5, 1x5
Catalog IDEN300-180978
Product class Building Block
Nametert-butyl 3-amino-3-carbamoylazetidine-1-carboxylate
ACD numberMFCD21842621
CAS number1254120-14-3
Formula
MW215.2
CLogP0.165
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-300141
Product class Building Block
Namerac-tert-butyl (3R,5R)-3-amino-5-fluoropiperidine-1-carboxylate, trans
ACD numberMFCD28987727
CAS number1638772-27-6
Formula
MW218.3
CLogP1.677
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:5.8 g(5 business days)  
Catalog IDEN300-88878
Product class Building Block
Nametert-butyl N-{octahydrocyclopenta[c]pyrrol-4-yl}carbamate
ACD numberMFCD08234847
CAS number185693-12-3
Formula
MW226.3
CLogP1.539
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 5 g 1x0.25, 1x0.5, 1x1, 1x2.5, 1x5
Catalog IDEN300-341807
Product class Building Block
Nametert-butyl 5-amino-octahydrocyclopenta[c]pyrrole-2-carboxylate
ACD numberMFCD15071647
CAS number1031335-28-0
Formula
MW226.3
CLogP1.195
Storage conditions+4
Transport conditionsNormal
Now available as 91% pureGlobal stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-341851
Product class Building Block
Nametert-butyl 3-amino-6-azabicyclo[3.2.1]octane-6-carboxylate
ACD numberMFCD17016784
CAS number1199942-73-8
Formula
MW226.3
CLogP1.195
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:6.7 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-313870
Product class Building Block
Nametert-butyl 8-amino-5-azaspiro[3.4]octane-5-carboxylate
ACD numberMFCD30476272
CAS number2044714-40-9
Formula
MW226.3
CLogP1.998
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-370908
Product class Building Block
Namerac-tert-butyl (3aR,7aS)-octahydro-1H-pyrrolo[3,4-c]pyridine-5-carboxylate, cis
ACD numberMFCD22035710
CAS number1257389-94-8
Formula
MW226.3
CLogP1.694
Storage conditions-10
Transport conditionsIce pack
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-29519
Product class Building Block
Nametert-butyl N-{6-aminospiro[3.3]heptan-2-yl}carbamate
ACD numberMFCD09054707
CAS number1239589-52-6
Formula
MW226.3
CLogP0.878
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:3.3 g(5 business days)  
Catalog IDEN300-61204
Product class Building Block
Nametert-butyl N-{2-azabicyclo[2.2.1]heptan-1-ylmethyl}carbamate
ACD numberMFCD19442665
CAS number1221725-82-1
Formula
MW226.3
CLogP1.884
Storage conditions+4
Transport conditionsNormal
Now available as 91% pureGlobal stock:0.8 g(5 business days)  
Catalog IDEN300-90609
Product class Building Block
Nametert-butyl 1,7-diazaspiro[4.4]nonane-1-carboxylate
ACD numberMFCD08234442
CAS number885268-47-3
Formula
MW226.3
CLogP1.88
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-100953
Product class Building Block
Nametert-butyl 3,9-diazabicyclo[4.2.1]nonane-9-carboxylate
ACD numberMFCD18785763
CAS number1251015-63-0
Formula
MW226.3
CLogP1.88
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 5 g 1x0.25, 1x0.5, 1x1, 1x2.5, 1x5
Catalog IDEN300-41917
Product class Building Block
Nametert-butyl 1-amino-6-azaspiro[2.5]octane-6-carboxylate
ACD numberMFCD19440981
CAS number1233323-55-1
Formula
MW226.3
CLogP1.425
Storage conditions+4
Transport conditionsIce pack
Purity: 95%Global stock:> 10 g(5 business days)   EU Rush delivery(1 g)(2 business days)
1x0.25, 1x0.5, 1x1
Catalog IDEN300-64081
Product class Building Block
Nametert-butyl 1,7-diazaspiro[3.5]nonane-7-carboxylate
ACD numberMFCD14581195
CAS number1180112-41-7
Formula
MW226.3
CLogP1.322
Storage conditions+4
Transport conditionsNormal
Now available as 80% pureGlobal stock:> 10 g(5 business days)  
Catalog IDEN300-256607
Product class Building Block
Nametert-butyl 1,7-diazaspiro[3.5]nonane-1-carboxylate
ACD numberMFCD14581196
CAS number1216936-29-6
Formula
MW226.3
CLogP1.322
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.002, 1x0.005, 1x0.01, 1x0.02, 1x0.025, 1x0.05, 1x0.1, 1x0.25, 1x0.5, 1x1
Catalog IDEN300-344403
Product class Building Block
Namerac-tert-butyl (3aR,6aS)-3a-amino-octahydrocyclopenta[b]pyrrole-1-carboxylate, cis
ACD numberMFCD17016447
CAS number2059909-31-6
Formula
MW226.3
CLogP1.998
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-366826
Product class Building Block
Namerac-tert-butyl (3aR,6aS)-3a-methyl-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate, trans
ACD numberMFCD30737568
CAS number2095396-65-7
Formula
MW226.3
CLogP2.026
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.25, 1x0.5, 1x1
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