[(dimethylamino)({3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy})methylidene]dimethylazanium, hexafluoro-lambda5-phosphanuide

EN300-49821

Product class

Building Blocks

CAS number

148893-10-1

MW

380.10

Purity

95%

Stock Availability

UA, US, EU, DE

Lead time

1-5 days delivery time

Reagent for generation of an active ester from a carboxylic acid

HATU (Hexafluorophosphate Azabenzotriazole Tetramethyl Uronium) is a gold standard reagent in the field of peptide coupling, the primary purpose of which is to generate an active ester from carboxylic acid. Typically, it is used in DMF with Hünig's base (or TEA) to form an amide bond. No heating is required. By itself, HATU is a white powder, that is stable, and soluble in the polar aprotic solvent. It performs well in the case of hindered substrates when another coupling reagent can fail. This all makes HATU an excellent choice when you need a guarantee of a good result on a small scale because for a big scale, the price of HATU makes it too expensive[1].

Synonyms: O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate; 1H-1,2,3-Triazolo[4,5-b]pyridinium, 1-[bis(dimethylamino)methylene]-, 3-oxide; hexafluorophosphate(1-) (1:1) (ACI); 1H-1,2,3-Triazolo[4,5-b]pyridinium, 1-[bis(dimethylamino)methylene]-, hexafluorophosphate(1-), 3-oxide (9CI); 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate

1. N-[(Dimethylamino)-1H-1,2,3-Triazolo[4,5-b]Pyridin-1-Ylmethylene]-N-Methylmethanaminium Hexafluorophosphate N-Oxide. Albericio F.; Kates S. A.; Carpino L. A. Encyclopedia of Reagents for Organic Synthesis 2001. DOI: 10.1002/047084289X.rd312s

Name:

[(dimethylamino)({3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy})methylidene]dimethylazanium, hexafluoro-lambda5-phosphanuide

SMILES:

F[P-](F)(F)(F)(F)F.CN(C)C(ON1N=NC2=CC=CN=C21)=[N+](C)C

CAS number:

148893-10-1

CLogP:

-0.148

ACD number:

MFCD00274639

Dangerous good:

Yes

Class:

Other

Formula:

C₁₀H₁₅F₆N₆OP

Subclass:

Other

MW:

380.10

Product class:

Building Blocks