EN300-316330

Reagent for Mitsunobu reaction

CMBP, also known as Tsunoda reagent, is a stabilized trialkylphosphorane that serves as a versatile substitute for diethyl azodicarboxylate and triphenylphosphine in Mitsunobu reactions[1]. It exhibits comparable performance to triphenylphosphine and diethyl azodicarboxylate while combining their advantageous properties within a single molecule. What sets CMBP apart is its enhanced reactivity and compatibility with high temperatures, enabling the utilization of weakly acidic pronucleophiles beyond the typical pKa range for Mitsunobu reactions[2]. Additionally, CMBP offers a clean reaction profile, eliminating the need for phosphine nucleophile reagents and generating acetonitrile as an innocuous by-product, which often makes the process of purification simple. The CMBP-mediated reaction can be conducted at room temperature, yielding the desired product with exceptional yield and purity, but may require more time.