3-({bis[bis(propan-2-yl)amino]phosphanyl}oxy)propanenitrile

EN300-239576

Product class

Building Blocks

CAS number

102691-36-1

MW

301.41

Purity

90%

Stock Availability

UA, EU

Lead time

1-5 days delivery time

Reagent for phosphitylation of DNA or RNA fragments

2-Cyanoethyl tetraisopropylphosphorodiamidite is a phosphitylation reagent for DNA and RNA fragment synthesis that became very important in this field of study[1]. It is a colorless liquid that is shelf-stable well well-soluble in most organic solvents[2]. The reagent is stable for hydrolysis and offers an easy procedure that requires only an activator, such as (EN300-77565), and no heating. After the reaction, which usually takes one night, chromatography can easily purify the product.

Synonyms: bis(N,N-diisopropylamino)-2-cyanoethoxyphosphine; (2-cyanoethoxy) bis(N,N-diisopropylamino)- phosphine, 2-cyanoethyl N,N,N,N -tetraisopropylphosphordiamidite

1.Highly Efficient Chemical Synthesis of 2′-O-Methyloligoribonucleotides and Tetrabiotinylated Derivatives; Novel Probes That Are Resistant to Degradation by RNA or DNA Specific Nucleases. Sproat B. S.; Lamond A. I.; Beijer B.; Neuner P.; Ryder U. Nucleic Acids Res 1989, 17 (9), 3373–3386. DOI: 10.1093/nar/17.9.3373 2. 2-Cyanoethyl Tetraisopropylphosphorodiamidite. Beaucage S. L. Encyclopedia of Reagents for Organic Synthesis 2003. DOI: 10.1002/047084289X.rn00312

Name:

3-({bis[bis(propan-2-yl)amino]phosphanyl}oxy)propanenitrile

SMILES:

CC(C)N(C(C)C)P(OCCC#N)N(C(C)C)C(C)C

CAS number:

102691-36-1

CLogP:

3.901

ACD number:

MFCD00012213

Dangerous good:

Yes

Class:

Lab Reagents

Formula:

C₁₅H₃₂N₃OP

Subclass:

Nitriles

MW:

301.41

Product class:

Building Blocks