Reagent for the coupling of peptides, and synthesis of amides and esters
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, commonly known as EDC, is a versatile reagent extensively used for peptide coupling and the synthesis of amides and esters. Comparable to 1,3-Dicyclohexylcarbodiimide (DCC) and other carbodiimides, EDC exhibits similar reactivity. However, EDC offers a notable advantage over DCC: the urea byproduct it generates is water-soluble, enabling easy extraction and purification. As a hygroscopic white powder, EDC displays good solubility in most organic solvents. When combined with N-hydroxysuccinimide (NHS), EDC proves highly effective in conjugating smaller molecules, such as small peptides or fluorescent tags, to larger biomolecules in aqueous solutions. This versatile approach allows for the conjugation of various compounds, including proteins, DNA/RNA, and antibodies[1].
Synonyms: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; (3-{[(ethylimino)methylidene]amino}propyl)dimethylamine hydrochloride; 1,3-Propanediamine, N′-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride (9CI); Carbodiimide, [3-(dimethylamino)propyl]ethyl-, monohydrochloride (8CI); 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide monohydrochloride; 1-Ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride; 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride; 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide monohydrochloride; 3-[3-(Dimethylamino)propyl]-1-ethylcarbodiimide hydrochloride; [3-(Dimethylamino)propyl]ethylcarbodiimide hydrochloride; N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride; N-[(Ethylimino)methylene]-N′,N′-dimethylpropane-1,3-diamine hydrochloride; N-[3-(Dimethylamino)propyl]-N1-ethylcarbodiimide hydrochloride; N-Ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride; N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride
1. 1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride.
Pottorf R. S.; Szeto P.; Srinivasarao M. Organic Synthesis 2017, 1–5. DOI: 10.1002/047084289X.re062.pub2
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