thiolan-2-imine hydrochloride
EN300-211426
Product class
Building Blocks
CAS number
4781-83-3
MW
137.63
Purity
95%
Stock Availability
UA, US
Lead time
1-5 days delivery time
Reagent for thiolation of primary amines
Traut’s reagent cyclic thioimidate compound for the thiolation of primary amines and can be used for peptides or aminoglycosides[1]. It is a white crystalline powder that is soluble in water, methanol, and DMSO[1]. The reagent also can react with a hydroxy group, but this reaction is much slower than with amines (approximately 100 times slower)[1]. Traut’s reagent is found in application in the field modification of biological molecules for their further conjugation with other macromolecules, surfaces, markers, and cross-linking[2].
Synonyms: 2-iminothiolane hydrochloride; Dihydro-2(3H)-thiophenimine Hydrochloride
1. Dihydro-2(3 H )-Thiophenimine Hydrochloride. Pushechnikov A.; Disney M. D. Encyclopedia of Reagents for Organic Synthesis 2009. DOI: 10.1002/047084289X.rn01096 2. Thiolated-Chitosan: A Novel Mucoadhesive Polymer for Better-Targeted Drug Delivery. Tekade M.; Maheshwari N.; Youngren-Ortiz S. R.; Pandey V.; Chourasiya Y. et al. Biomaterials and Bionanotechnology 2019, 459–493. DOI: 10.1016/B978-0-12-814427-5.00013-5
Name:
thiolan-2-imine hydrochloride
SMILES:
Cl.N=C1CCCS1
CAS number:
4781-83-3
Product class:
Building Blocks
ACD number:
MFCD00039013
CLogP:
0.271
Class:
Other
Formula:
C4H8ClNS
Subclass:
Other
MW:
137.63