EN300-195971

Reagent for electrophilic trifluoromethylation

This reagent is used for direct electrophilic trifluoromethylation of many nucleophiles[1], [2]. It is a white solid that is soluble in most organic solvents and has similar properties to the Togni II reagent[2]. As a Togni II reagent, it is capable of selective reaction with thiols to yield corresponding thioethers. However, this reagent is less reactive and offers a softer approach, has unique properties, and is mainly used for reactions with β-keto esters or α-nitro carbonyl compounds[1], [3]. Recently was developed a methodology for trifluoromethylarylation of alkenes with anilines and the title reagent, which offers good yields and utilizes no additives, transition metals, photocatalysts, or an excess of reagents[2]. While the Togni II reagent doesn’t undergo or give low yields with this methodology.