tris(2,2,2-trifluoroethyl) borate
EN300-18543889
Product class
Building Blocks
CAS number
659-18-7
MW
307.91
Purity
95%
Stock Availability
UA, US
Lead time
1-5 days delivery time
Reagent for amide coupling
Tris(2,2,2-trifluoroethoxy)boron, also known as the Sheppard amidation reagent, is a highly effective amide coupling agent used to form amides from carboxylic acids and amines1. It operates under mild conditions and after the reaction completion, there is no need for aqueous workup or chromatography because the filtration is enough for efficient product separation. The reagent is a colorless liquid, soluble in most organic solvents, and should be handled with care due to its irritant and flammable nature.
Synonyms: Sheppard amidation reagent; Boric Acid Tris(2,2,2-trifluoroethyl) Ester
1. Sheppard, T. Tris(2,2,2-Trifluoroethoxy)Boron. In Encyclopedia of Reagents for Organic Synthesis; John Wiley & Sons, Ltd: Chichester, UK, 2014; pp 1–2. https://doi.org/10.1002/047084289X.rn01754
Name:
tris(2,2,2-trifluoroethyl) borate
SMILES:
FC(F)(F)COB(OCC(F)(F)F)OCC(F)(F)F
CAS number:
659-18-7
CLogP:
-1.033
ACD number:
MFCD00093768
Dangerous good:
Yes
Class:
Other
Formula:
C6H6BF9O3
Subclass:
Other
MW:
307.91
Product class:
Building Blocks