3-[bis(2-carboxyethyl)phosphanyl]propanoic acid hydrochloride

EN300-1724932

Product class

Building Blocks

CAS number

51805-45-9

MW

286.65

Purity

95%

Stock Availability

UA

Lead time

from 7 days delivery time

Reagent for reduction of disulfides, sulfoxides, sulfonyl chlorides, N-oxides, and azides

Tris(2-carboxyethyl)phosphine hydrochloride or TCEP is a versatile reagent that is able to reduce disulfides, sulfoxides, sulfonyl chlorides, N-oxides, and azides[1]. It is a white crystalline solid, that is well soluble in water. Besides being air-stable, water-soluble, and odorless, TCEP is also pH tolerant, buffers in aqueous media, and tolerates a variety of functional groups under synthetic, biological, and physiological conditions as a reducing reagent. TCEP is found to be a suitable reducing agent for the Staudinger reaction in bioconjugation and peptide ligation and also it is often employed for thiol (as disulfide) deprotection.

Synonyms: TCEP hydrochloride; TCEP-HCl; Propanoic acid, 3,3′,3′′-phosphinidynetris-, hydrochloride

1. Tris(2-Carboxyethyl)Phosphine Hydrochloride. Yost J. M.; Knight J. D.; Coltart D. M.; Li E. W. Encyclopedia of Reagents for Organic Synthesis 2018, 1–9. DOI: 10.1002/047084289X.rn00973.pub2

Name:

3-[bis(2-carboxyethyl)phosphanyl]propanoic acid hydrochloride

SMILES:

Cl.O=C(O)CCP(CCC(=O)O)CCC(=O)O

CAS number:

51805-45-9

CLogP:

-1.956

ACD number:

MFCD00145469

Dangerous good:

Yes

Class:

Other

Formula:

C₉H₁₆ClO₆P

Subclass:

Other

MW:

286.65

Product class:

Building Blocks