EN300-1664590

Reagent for bromination

Triphenylphosphine dibromide is a reagent with many applications, primarily, converting alcohols, phenols, enols, ethers, and acetals into alkyl bromides, or carboxylic acid derivatives into acyl bromides1. This method can be applied to sensitive substrates that contain cyclopropyl rings (e.g., cyclopropyl carbinol) or unsaturated compounds (e.g., cinnamyl alcohol and alkynediols), with minimal or no side reactions. Additionally, It facilitates the cyclization of amino alcohols to cyclic amines and can dehydrate and brominate carboxamide groups. It is a hygroscopic solid that is moisture-sensitive and corrosive, requiring careful handling during the work, and storage in a cool, dry place.