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Duvelisib Retrosynthesis

Duvelisib (COPIKTRA™, Verastem, Inc.) is dual inhibitor of PI3Kδ and PI3Kγ which was approved by FDA for adult patients with relapsed or refractory chronic lymphocytic leukemia (CCL) or small lymphocytic lymphoma (SLL) after at least two prior therapies on September 24, 2018.

Synthesis of this small molecule may be realized starting from these Building Blocks:

Duvelisib retrosynthesis

 

Here are some analogs and similar Building Blocks, available from stock:

5-iodo-2,3-dimethylbenzoic acid 5-iodo-2,4-dimethylbenzoic acid 2-propylbenzoic acid 3-iodo-2-methylbenzoic acid 5-iodo-2-methylbenzoic acid 2-iodo-6-methylbenzoic acid 2-(2-methylpropyl)benzoic acid 2-fluoro-4,6-dimethylbenzoic acid 4-fluoro-2,6-dimethylbenzoic acid 3-fluoro-2-methylbenzoic acid 2-ethyl-5-fluorobenzoic acid 2,3,6-trimethylbenzoic acid 4-chloro-2,5-dimethylbenzoic acid 4-chloro-2,6-dimethylbenzoic acid 2-chloro-6-methylbenzoic acid 2-chloro-6-methylbenzene-1-sulfonyl chloride 3-bromo-2,6-dimethylbenzoic acid 4-bromo-2,5-dimethylbenzoic acid 4-bromo-2,6-dimethylbenzoic acid 3-BROMO-2-METHYLBENZOIC ACID 5-bromo-2-methylbenzoic acid 2-Bromo-6-methylbenzoic acid 3-chloro-2-methylbenzoic acid 2-Fluoro-6-methylbenzoic acid2-amino-2-(1-methylcyclopropyl)acetic acid hydrochloride 2-amino-2-cyclobutylacetic acid hydrochloride 2-amino-3-cyclopropylbutanoic acid hydrochloride 2-amino-2-(2-methylcyclopropyl)acetic acid, Mixture of diastereomers 2-amino-2-cyclopropylacetic acid 2-amino-3,3-dimethylpentanoic acid hydrochloride 2-amino-4,4-dimethylpentanoic acid hydrochloride 2-amino-2-[1-(trifluoromethyl)cyclopropyl]acetic acid 2-amino-4-fluorobutanoic acid hydrochloride (2S)-2-amino-4,4-difluorobutanoic acid hydrochloride 2-amino-4,4,4-trifluorobutanoic acid 2-amino-3,3,3-trifluoropropanoic acid 2-amino-3-ethylpentanoic acid hydrochloride 2-amino-3,4-dimethylpentanoic acid (2R)-2-amino-3-fluoro-4-methylpentanoic acid hydrochloride (2S)-2-amino-5,5,5-trifluoropentanoic acid hydrochloride 2-amino-3,3-difluoropentanoic acid 2-amino-4,4-difluoropentanoic acid hydrochloride (2S)-2-aminopropanoic acid 2-aminopent-4-enoic acid 2-amino-4-methylpent-4-enoic acid 2-amino-2-cyclopropyl-3,3,3-trifluoropropanoic acid 2-amino-3-methyl-2-(trifluoromethyl)butanoic acid 2-amino-2-(trifluoromethyl)butanoic acid hydrochloride 2-amino-3,3,3-trifluoro-2-methylpropanoic acid 2-amino-3,3-difluoro-2-methylpropanoic acid hydrochloride 2-amino-4-fluoro-2-methylbutanoic acid hydrochloride 2-amino-4-methyl-2-(trifluoromethyl)pentanoic acid 2-amino-2,3-dimethylpentanoic acid hydrochloride 2-amino-2-cyclopropylpropanoic acid 2-amino-2-(1-methylcyclopropyl)propanoic acid hydrochloride 2-amino-2-methylbutanoic acid hydrochloride 2-amino-2-ethylbutanoic acid 2-amino-2-methylhexanoic acid hydrochloride 2-amino-2-methylpentanoic acid7H-purine-6-carboxylic acid 9H-purine-6-sulfonic acid 9H-purine-6-sulfonyl fluoride 6-chloro-2-(trifluoromethyl)-3H-purine 6-chloro-7H-purine 6-chloro-8-(trifluoromethyl)-9H-purine 6-chloro-9-cyclopropyl-9H-purine 6-chloro-9-ethyl-9H-purine 6-chloro-9-methyl-9H-purine 6-chloro-8,9-dihydro-7H-purin-8-one