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Glasdegib Retrosynthesis

Glasdegib (DAURISMO®, Pfizer) is an inhibitor of the Sonic hedgehog pathway (Shh) which was approved by FDA for newly-diagnosed acute myeloid leukemia (AML) in patients who are 75 years old or older or who have comorbidities that preclude intensive induction chemotherapy on November 21, 2018.

Synthesis of this small molecule may be realized starting from these Building Blocks:

Glasdegib retrosynthesis

 

Here are some analogs and similar Building Blocks, available from stock:

2-isocyanatobenzonitrile 4-AMINO-3-(TRIFLUOROMETHYL)BENZONITRILE 4-amino-2-(trifluoromethyl)benzonitrile 3-fluoro-4-(methylamino)benzonitrile 4-amino-2,5-difluorobenzonitrile 4-amino-3,5-difluorobenzonitrile 4-amino-3-fluorobenzonitrile 4-amino-2-fluorobenzonitrile 4-aminobenzonitrile 4-(methylamino)benzonitrile 4-(ethylamino)benzonitrile 4-amino-3-ethylbenzonitrile 4-azidobenzonitrile 2-fluoro-4-isocyanatobenzonitrile 4-isocyanatobenzonitrile (4-cyanophenyl)urea N-(4-cyanophenyl)aminosulfonamide 3-isocyanatobenzonitrile4-methoxypyridine 1-tert-butyl 2-methyl 4-aminopiperidine-1,2-dicarboxylate rac-(2R,4S)-1-[(tert-butoxy)carbonyl]-4-hydroxypiperidine-2-carboxylic acid, cis methyl 1-methyl-4-oxopiperidine-2-carboxylate 4-methoxy-2-methylpyridine 4-{[(tert-butoxy)carbonyl]amino}pyridine-2-carboxylic acid 4-(benzylamino)pyridine-2-carboxylic acid5,6-difluoro-1H-1,3-benzodiazole 4-fluoro-1H-1,3-benzodiazole 5-ethyl-1H-1,3-benzodiazole hydrochloride  https://enaminestore.com/catalog/EN300-174276	Benzimidazole 5-methyl-1H-1,3-benzodiazole 5-fluoro-1-methyl-1H-1,3-benzodiazole 4,5-dimethyl-1H-1,3-benzodiazole 5,6-dimethyl-1H-benzo[d]imidazole