EnamineStore Blog

New products at Enamine

New innovative products at Enamine, including novel building blocks, screening compounds, fragments and bioactive compounds.

Hunting For New Drug Discovery Ideas In The CLOUD

   by Andrii Buvailo  
Hunting For New Drug Discovery Ideas In The CLOUD

Patient diversity and developing drug resistance can undermine the efficiency of existing therapies in a long-term pharmacological treatment of diseases, such as cancer and infections.  

One of the promising strategies, in this case, is applying multicomponent therapeutics, leading the way to more personalized medicine. Approved drugs appear to be the ideal starting point for the development of novel multidrug treatments enjoying a fast track to new clinical applications.

Indeed, they are already known to be safe, effective and bioavailable. Last, but not least, they usually have well-defined targets and mechanisms of action.

Another important strategy in modern pharmaceutical research is drug repurposing. Drugs which once failed as effective treatments for one disease might well become “blockbuster” cures for another.

Expanding Horizons for Fragment Based Drug Discovery (FBDD)

   by Andrii Buvailo  
Expanding Horizons for Fragment Based Drug Discovery (FBDD)

Scientists estimated that the human genome encodes above 20,000 different proteins in our body. However, available public databases contain records of known ligands for only about 10% of all proteins. The rest of proteins remains either not yet properly explored, or is labelled “undruggable”.

A recent study published in Cell, however, pushes the limits of the current state of the art in the area of protein-ligand interactions, facilitating a coordinated discovery of new bioactive small molecules and their molecular targets.