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Larotrectinib Retrosynthesis

Larotrectinib Retrosynthesis

Larotrectinib (VITRAKVI®, Loxo Oncology Inc. and Bayer) is an inhibitor of receptors TrkA, TrkB, and TrkC which was approved by FDA for adult and pediatric patients with solid tumors that have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion without a known acquired resistance mutation, that are either metastatic or where surgical resection is likely to result in severe morbidity, and who have no satisfactory alternative treatments or whose cancer has progressed following treatment on November 26, 2018.

Lofexidine Retrosynthesis

Lofexidine Retrosynthesis

Lofexidine (Lucemyra®, US Woldmeds LLC) is a medication historically used to treat high blood pressure which was approved by FDA as a first non-opioid drug for the mitigation of withdrawal symptoms to facilitate abrupt discontinuation of opioids in adults on May 16, 2018. Lucemyra is not a treatment for opioid use disorder (OUD), but can be used as part of a broader, long-term treatment plan for managing OUD.

Enamine Building Blocks Faster in Your Lab

Enamine Building Blocks Faster in Your Lab

Enamine has the world’s largest catalogue of building blocks which is monthly enriched with ca. 2,000 newly designed and synthesized compounds. Most of these compounds have been previously unknown and may already provide elegant solutions to your today’s challenges.

eProcurement is Easy With Enamine

PunchOut      by Andrii Buvailo  
eProcurement is Easy With Enamine

Being the global leader in supplying state-of-the-art chemical products for drug discovery (building blocks and screening compounds), Enamine also created a sophisticated ecommerce integration layer, allowing for a seamless eProcurment process to be enabled between buyers and vendors.

REAL Compound Sales: Hit Exploration in REAL database

REAL Compound Sales: Hit Exploration in REAL database
Title: REAL Compound Sales: Hit Exploration in REAL database
 
Product range: REAL Database
 
Promotional period: July 23, 2018 – December 31, 2018
 
Prize: Immediate 20% discount on purchase of the analogs requested through EnamineStore functionality “Hit Exploration in REAL database, 680 million compounds searched”
 
Discount policy: 20% Discount applies only to the requests received from EnamineStore website. Please draw you hit molecule, search and select REAL analogue compounds. Upon sending your request using the corresponding button you will be granted with the said discount provided you confirm the order to our sales manager