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Isoniazid

Isonicotinic acid hydrazide, Isonicotinohydrazide, Nydrazid, Laniazid, Rimifon, INH

Technical Data

Chemical name:Isoniazid
Formula:C6H7N3O
Molecular weight:137.1
CAS number:54-85-3
SMILES:NNC(=O)c1ccncc1

Cat. No. BRC0171

BRC0171

Prices

1.0 mg $ 55.0
2.0 mg $ 56.0
5.0 mg $ 59.0
10.0 mg $ 78.0
20.0 mg $ 93.0
25.0 mg $ 100.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-infective    Antibacterial   

Target:

Enzymes    Cytochrome P450 (CYP)    Dihydrofolate Reductase (DHFR)    Reductases    Peroxidases   

Description:

Isoniazid is a bactericidal agent active against organisms of the genus Mycobacterium, specifically M. tuberculosis, M. bovis and M. kansasii. It is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complex.

Targets:Catalase-peroxidase, Enoyl-[acyl-carrier-protein] reductase [NADH], Cytochrome P450 2C8, Cytochrome P450 1A2, Cytochrome P450 3A4, Cytochrome P450 2C19, Dihydrofolate reductase
References:
1. J Bacteriol. 2004; 186, 5427-31.; 
2. Epilepsia. 1975; 16, 393-402.;