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Mesalazine

5-ASA, Asacol, Asacolitin, Canasa, Claversal, Fisalamine, Iialda, Lixacol, m-Aminosalicylic acid, P-Aminosalicylsaeure, Pentasa, Rowasa, Salofalk

Technical Data

Chemical name:Mesalazine
Formula:C7H7NO3
Molecular weight:153.1
CAS number:89-57-6
SMILES:Nc1ccc(O)c(c1)C(O)=O

Cat. No. BRC0168

BRC0168

Prices

1.0 mg $ 55.0
2.0 mg $ 56.0
5.0 mg $ 59.0
10.0 mg $ 78.0
20.0 mg $ 93.0
25.0 mg $ 100.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Analgesics    Anti-Inflammatory   

Target:

Kinases    IκB kinase (IKK)    Other kinases    Enzymes    Kinases    Other Oxidases    Peroxidases    Nuclear Receptors (nuclear hormone receptors)    Peroxisome proliferator-activated receptor (PPAR)   

Description:

An anti-inflammatory agent, structurally related to the salicylates, which is active in inflammatory bowel disease. It is considered to be the active moiety of sulphasalazine. 

Targets:Prostaglandin G/H synthase 2, Prostaglandin G/H synthase 1, Arachidonate 5-lipoxygenase, Peroxisome proliferator-activated receptor gamma, Inhibitor of nuclear factor kappa-B kinase subunit alpha, Inhibitor of nuclear factor kappa-B kinase subunit beta, Myeloperoxidase, Arylamine N-acetyltransferase
References:
1. Drugs R D. 2016 Mar; 16(1):35-43.; 
2. Adv Ther. 2016 Mar; 33(3):400-9.;