EnamineStore

Welcome, Guest
Tutorials

Return to Search menu

Apocynin

NSC 209524; NSC 2146;

Technical Data

Chemical name:Apocynin
Formula:C9H10O3
Molecular weight:166.2
CAS number:498-02-2
SMILES:COC1=C(O)C=CC(=C1)C(C)=O

Cat. No. BRC1066

BRC1066

Prices

1.0 mg $ 55.0
2.0 mg $ 56.0
5.0 mg $ 59.0
10.0 mg $ 78.0
20.0 mg $ 93.0
25.0 mg $ 100.0

Make inquiry

Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Analgesics    Anti-Inflammatory    CNS Agents   

Target:

G-Protein-Coupled Receptors (GPCRs)    Glutamate receptor    Enzymes    Other Oxidases    Enzyme-Linked Receptors    Cytokine receptors    Ion Channels    Ligand-gated ion channels    Transporters    Ion Pumps   

Description:

Apocynin is a methoxy-substituted catechol that is commonly used as a selective NADPH-oxidase inhibitor with IC50 of 10 μM. Acts as an antioxidant in endothelial cells and vascular smooth muscle cells.

Targets:Glutamate receptor ionotropic, NMDA 2D; Tumor necrosis factor; NADPH oxidase;
References:
1. Biochem Biophys Res Commun. 2009; 384, 1, 87 - 92.; 2. Br J Pharmacol. 2006; 148, 4, 544 - 552.; 3. Med Chem. 2017; 13, 1, 93 - 100.;