BW-755C is a dual inhibitor of both cyclooxygenase and lipoxygenase pathways. It exerts an anti-inflammatory effect by inhibiting the formation of prostaglandins and leukotrienes. The drug also enhances pulmonary hypoxic vasoconstriction and has a protective effect after myocardial ischemia.
5-LO, COX-1, COX-2
1. J Med Chem. 1990 May; 33(5):1491-6.;
2. J Med Chem. 1991 May; 34(5):1560-70.;