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Trimethoprim

Proloprim, Trimpex, Monotrim, Bactramin, BW 56-72, NIH 204, NSC-106568

Technical Data

Chemical name:Trimethoprim
Formula:C14H18N4O3
Molecular weight:290.3
CAS number:738-70-5
SMILES:COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC

Cat. No. BRC0144

BRC0144

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-infective    Antimalarial   

Target:

Enzymes    Cytochrome P450 (CYP)    Dihydrofolate Reductase (DHFR)    Reductases    Multidrug Transporter Inhibitors    P-glycoprotein/ABCB1   

Description:

Trimethoprim is a pyrimidine analogue that disrupts folate synthesis, an essential part of the thymidine synthesis pathway. Inhibition of the enzyme starves the bacteria of nucleotides necessary for DNA replication.The drug, therefore, exhibits bactericidal activity.

Targets:Thymidylate synthase, Dihydrofolate reductase
References:
1. J Chemother. 1993 Dec; 5(6):465-9.; 
2. J Chemother. 1994 Feb; 6(1):3-11.; 
3. J Antimicrob Chemother. 2005 Nov; 56(5):962-4.; 
4. J Antimicrob Chemother. 2002 Sep; 50 Suppl S1:25-37.; 
5. Lancet. 2002 Jun 29; 359(9325):2249-51.;