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Niflumic Acid

Lopac-N-0630; UP 83; NFA; Niflugel; Actol; Donalgin; Nifluril;

Technical Data

Chemical name:Niflumic Acid
Formula:C13H9F3N2O2
Molecular weight:282.2
CAS number:4394-00-7
SMILES:OC(=O)C1=C(NC2=CC(=CC=C2)C(F)(F)F)N=CC=C1

Cat. No. BRC0980

BRC0980

Prices

1.0 mg $ 61.0
2.0 mg $ 62.0
5.0 mg $ 65.0
10.0 mg $ 86.0
20.0 mg $ 94.0
25.0 mg $ 102.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Analgesics    Anti-Inflammatory    CNS Agents   

Target:

Enzymes    Cyclooxygenase (COX)    Lipases    Ion Channels    Chloride channel   

Description:

Niflumic acid is a nonsteroidal anti-inflammatory fenamate, is a Ca2+-activated Cl- channel blocker. It inhibits both phospholipase A2 as well as COX-2.

Targets:Phospholipase A2; Prostaglandin G/H synthase 2; Chloride channel protein ClC-Ka; Prostaglandin G/H synthase 1; Cytosolic phospholipase A2; UDP-glucuronosyltransferase 1-9;
References:
1. Biochem J. 2004; 377, 3, 675 - 684.; 2. Biophys J. 1994; 67(6), 2272-9.; 3. Pflugers Arch. 2010; 459(4), 579-92.;