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NSC 59984

Technical Data

Chemical name:NSC 59984
Formula:C12H15N3O4
Molecular weight:265.3
CAS number:803647-40-7
SMILES:CN1CCN(CC1)C(=O)C=Cc1ccc(o1)[N+]([O-])=O

Cat. No. BRC0915

BRC0915

Prices

1.0 mg $ 88.0
2.0 mg $ 91.0
5.0 mg $ 96.0
10.0 mg $ 125.0
20.0 mg $ 240.0
25.0 mg $ 280.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-cancer agents    Anti-Inflammatory   

Target:

Enzyme-Linked Receptors    Toll-like receptor   

Description:

NSC59984 restores wild-​type p53 signaling via p73 activation, specifically in mutant p53-​expressing colorectal cancer cells. It synergizes with CPT11 to induce cell death in mutant p53-​expressing colorectal cancer cells and inhibits mutant p53-​assocd. colon tumor xenograft growth in a p73-​dependent manner in vivo.

Targets:Toll-like receptor 2, Toll-like receptor 1
References:
1. Angew. Chem. 2012; 51, 49, 12246 - 12249.; 
2. Cancer Res. 2015; 75(18), 3842-3852.; 
3. PCT Int. Appl. 2014; WO 2014022287 A1 20140206.;