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5-{2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-5-methyl-4,6-dioxo-2H,4H,5H,6H,7H-pyrazolo[3,4-d]pyrimidin-3-yl}-1-methyl-1H-pyrrole-3-carbonitrile

Technical Data

Chemical name:5-{2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-5-methyl-4,6-dioxo-2H,4H,5H,6H,7H-pyrazolo[3,4-d]pyrimidin-3-yl}-1-methyl-1H-pyrrole-3-carbonitrile
Formula:C26H22ClN7O2
Molecular weight:500.0
CAS number:946411-72-9
SMILES:CN1C=C(C=C1C1=C2C(=NN1CC1=C3C=C(Cl)C=CC3=NC=C1)N(CC1CC1)C(=O)N(C)C2=O)C#N

Cat. No. BRC0671

BRC0671

Prices

1.0 mg $ 284.0
2.0 mg $ 295.0
5.0 mg $ 440.0
10.0 mg $ 873.0
20.0 mg $ 1309.0
25.0 mg $ 1571.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-infective    Antibacterial   

Target:

G-Protein-Coupled Receptors (GPCRs)    Glutamate receptor   

Description:

The compound is selective Helicobacter pylori glutamate racemase inhibitor (IC50 = 25 nM).

Targets:Glutamate racemase;
References:
1. Nature. 2007; 447(7146), 817-822.; 2. Antimicrob. Agents Chemother. 2009; 53(8), 3331-3336.; 3. Bioorg. Med. Chem Letters. 2008; 18(16), 4716-4722.;