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({1-[(2-chlorophenyl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl}methyl)[3-(4-ethoxyphenoxy)-2-methoxypropyl]methylamine

Technical Data

Chemical name:({1-[(2-chlorophenyl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl}methyl)[3-(4-ethoxyphenoxy)-2-methoxypropyl]methylamine
Formula:C26H34ClN3O3
Molecular weight:472.0
CAS number:1280193-99-8
SMILES:CCOC1=CC=C(OCC(CN(C)CC2=C(C)N(CC3=C(Cl)C=CC=C3)N=C2C)OC)C=C1

Cat. No. BRC0670

BRC0670

Prices

1.0 mg $ 83.0
2.0 mg $ 86.0
5.0 mg $ 91.0
10.0 mg $ 119.0
20.0 mg $ 205.0
25.0 mg $ 225.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Analgesics    Anticonvulsants    Antidiabetic    Cardiovascular   

Target:

Enzyme-Linked Receptors    Toll-like receptor   

Description:

The compound is Toll-like receptor 4 inhibitor (IC50 = 19.8 µM). It displays TLR4-mediated inflammation inhibition, potential antiseptic.

Targets:Toll-like receptor 4;
References:
1. J. Med. Chem. 2011; 54(13), 4659-4669.; 2. U.S. 2014; US 8642614 B2 20140204.; 3. PCT Int. Appl. 2011; WO 2011038152 A2 20110331.;