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Guanfacine hydrochloride

Estulic, Guanfacina, Guanfacinum, Estulic, SPD 503

Technical Data

Chemical name:Guanfacine hydrochloride
Formula:C9H10Cl3N3O
Molecular weight:282.6
CAS number:29110-48-3
SMILES:Cl.NC(N)=NC(=O)Cc1c(Cl)cccc1Cl

Cat. No. BRC0273

BRC0273

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 140.0
25.0 mg $ 160.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Antihypertensive    Cardiovascular    CNS Agents    Neurotransmitter Agents   

Target:

G-Protein-Coupled Receptors (GPCRs)    Adrenergic receptor   

Description:

Guanfacine selectively stimulates central alpha(2)-adrenergic receptors, resulting in inhibition of sympathetic vasomotor centers, which contributes predominantly to the hypotensive effects of the drug.

Targets:Alpha-2A adrenergic receptor, Alpha-2B adrenergic receptor
References:
1. J.Pharmacol.Exp.Ther. 1997; 281, 48.; 
2. Eur.J.Pharmacol. 1991; 202, 235.;