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Aminoglutethimide

BA 16038;

Technical Data

Chemical name:Aminoglutethimide
Formula:C13H16N2O2
Molecular weight:232.3
CAS number:125-84-8
SMILES:CCC1(CCC(=O)NC1=O)C1=CC=C(N)C=C1

Cat. No. BRC0623

BRC0623

Prices

1.0 mg $ 57.0
2.0 mg $ 58.0
5.0 mg $ 62.0
10.0 mg $ 82.0
20.0 mg $ 98.0
25.0 mg $ 105.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-cancer agents   

Target:

Enzymes    Cytochrome P450 (CYP)    Aromatases   

Description:

Aminoglutethimide is an aromatase inhibitor that blocks the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer.

Targets:Cytochrome P450 19A1; Cholesterol side-chain cleavage enzyme, mitochondrial;
References:
1. J Med Chem. 1990; 33, 9, 2673 - 2679.; 2. Bioorg Med Chem. 2005; 13, 23, 6571 - 6577.; 3. Steroids. 1995; 60, 5, 423 - 427.;