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Caffeine

Methyltheobromine, NSC 5036

Technical Data

Chemical name:Caffeine
Formula:C8H10N4O2
Molecular weight:194.2
CAS number:58-08-2
SMILES:Cn1cnc2n(C)c(=O)n(C)c(=O)c12

Cat. No. BRC0295

BRC0295

Prices

1.0 mg $ 55.0
2.0 mg $ 56.0
5.0 mg $ 59.0
10.0 mg $ 78.0
20.0 mg $ 93.0
25.0 mg $ 100.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

CNS Agents   

Target:

Kinases    Phosphatidylinositol 3-kinase (PDK)    G-Protein-Coupled Receptors (GPCRs)    Adenosine receptor    Enzymes    Kinases    Phosphodiesterases (PDE)    Ion Channels    Ryanodine Receptor    DNA    SUBDNA    Transporters    Ion Pumps    Multidrug Transporter Inhibitors    P-glycoprotein/ABCB1   

Description:

Central nervous system stimulant. Antagonist at A1 and A2A adenosine receptors and inhibitor of cyclic nucleotide phosphodiesterases. Mobilizes calcium from intracellular stores and inhibits benzodiazepine binding to GABA receptors.

Targets:Adenosine receptor A1, Adenosine receptor A2a, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, Ryanodine receptor 1, Cyclic nucleotide phosphodiesterase, DNA-dependent protein kinase catalytic subunit, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Inositol 1,4,5-trisphosphate receptor, Serine-protein kinase ATM
References:
1. J.Neuroinflammation. 2008; 5, 12.; 
2. Cell.Mol.Life Sci. 2004; 61, 857.; 
3. Brain Res.Brain Res.Rev. 1992; 17, 139.;