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Leflunomide

Arava, HW 486, Avara, SU 101

Technical Data

Chemical name:Leflunomide
Formula:C12H9F3N2O2
Molecular weight:270.2
CAS number:75706-12-6
SMILES:Cc1oncc1C(=O)Nc1ccc(cc1)C(F)(F)F

Cat. No. BRC0243

BRC0243

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Target:

Kinases    Other kinases    Enzymes    Kinases    Dehydrogenase    Enzyme-Linked Receptors    Receptor Tyrosine Kinase   

Description:

Leflunomide is a pyrimidine synthesis inhibitor indicated in adults for the treatment of active rheumatoid arthritis (RA).

Targets:Dihydroorotate dehydrogenase (quinone), mitochondrial, Aryl hydrocarbon receptor, Protein-tyrosine kinase 2-beta
References:
1. Clin Ther. 1999 Nov; 21(11):1837-52; discussion 1821.; 
2. Clin Ther. 2004 Apr; 26(4):447-59.; 
3. Am J Med Sci. 2002 Apr; 323(4):190-3.; 
4. Ann Rheum Dis. 2000 Nov; 59(11):841-9.;