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Captopril

C09AA01, SA-333, SQ-14225

Technical Data

Chemical name:Captopril
Formula:C9H15NO3S
Molecular weight:217.3
CAS number:62571-86-2
SMILES:C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O

Cat. No. BRC0890

BRC0890

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Antihypertensive    Cardiovascular   

Target:

G-Protein-Coupled Receptors (GPCRs)    Angiotensin receptor    Proteases    Proteases    Angiotensin-converting enzyme (ACE)   

Description:

Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS).

Targets:Angiotensin-converting enzyme, 72 kDa type IV collagenase, Matrix metalloproteinase-9, Leukotriene A-4 hydrolase, B1 bradykinin receptor
References:
1. Bioorg. Med. Chem. Lett. 2009; 19, 16, 4715 - 4719.; 
2. Mol. Pharmacol. 1997; 51, 6, 1070 - 1076.; 
3. J Agric Food Chem. 2013; 61, 45, 10685 - 10690.;