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Ramipril

Corpril, Delix, Ecator, HOE 498

Technical Data

Chemical name:Ramipril
Formula:C23H32N2O5
Molecular weight:416.5
CAS number:87333-19-5
SMILES:CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1[C@H]2CCC[C@H]2C[C@H]1C(O)=O

Cat. No. BRC0716

BRC0716

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Antihypertensive    Cardiovascular   

Target:

G-Protein-Coupled Receptors (GPCRs)    Angiotensin receptor    Proteases    Proteases    Angiotensin-converting enzyme (ACE)   

Description:

Ramipril is non-peptide, competitive angiotensin converting enzyme (ACE) inhibitor (IC50 = 5 nM). It is prodrug which is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on endothelium against high-glucose induced dysfunction.

Targets:Angiotensin-converting enzyme, B1 bradykinin receptor
References:
1. Curr Pharm Des. 2012; 18, 2, 220.; 
2. Bioorg. Med. Chem. 2013; 21, 15, 4485.; 
3. Bioorg. Med. Chem. 2015; 23, 13, 3526.;