Enflurane
Anesthetic 347; Alyrane;
Technical Data
| Chemical name: | Enflurane |
| Formula: | C3H2ClF5O |
| Molecular weight: | 184.5 |
| CAS number: | 13838-16-9 |
| SMILES: | FC(F)OC(F)(F)C(F)Cl |
Cat. No. BRC0687
Prices
Biological activity
| It belongs to next groups of Bioreference compounds: | |
| Therapeutic areas: | |
| Target: | G-Protein-Coupled Receptors (GPCRs) Glutamate receptor GABA receptors Ion Channels Potassium channel Ligand-gated ion channels Transporters Ion Pumps |
| Description: | Enflurane is an anesthetic. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. Enflurane acts as a positive allosteric modulator of the GABAA, glycine, and 5-HT3 receptors, and as a negative allosteric modulator of the AMPA, kainate, and NMDA receptors, as well as of nicotinic acetylcholine receptors. |
| Targets: | GABA-A receptor (anion channel); Glycine receptor (alpha-1/beta); Intermediate conductance calcium-activated potassium channel protein 4; Potassium voltage-gated channel subfamily A member 1; Calcium-transporting ATPase type 2C member 1; Glutamate receptor 1; ATP synthase subunit delta, mitochondrial; |
| References: | 1. Br J Anaesth. 2006; 97(5), 687-94.; 2. Anesthesiology. 2001; 94(6), 1026-33.; 3. Eur J Pharmacol. 2000; 395(2), 95-101.; |