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Enflurane

Anesthetic 347; Alyrane;

Technical Data

Chemical name:Enflurane
Formula:C3H2ClF5O
Molecular weight:184.5
CAS number:13838-16-9
SMILES:FC(F)OC(F)(F)C(F)Cl

Cat. No. BRC0687

BRC0687

Prices

1.0 mg $ 61.0
2.0 mg $ 62.0
5.0 mg $ 65.0
10.0 mg $ 86.0
20.0 mg $ 94.0
25.0 mg $ 102.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

CNS Agents   

Target:

G-Protein-Coupled Receptors (GPCRs)    Glutamate receptor    GABA receptors    Ion Channels    Potassium channel    Ligand-gated ion channels    Transporters    Ion Pumps   

Description:

Enflurane is an anesthetic. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. Enflurane acts as a positive allosteric modulator of the GABAA, glycine, and 5-HT3 receptors, and as a negative allosteric modulator of the AMPA, kainate, and NMDA receptors, as well as of nicotinic acetylcholine receptors.

Targets:GABA-A receptor (anion channel); Glycine receptor (alpha-1/beta); Intermediate conductance calcium-activated potassium channel protein 4; Potassium voltage-gated channel subfamily A member 1; Calcium-transporting ATPase type 2C member 1; Glutamate receptor 1; ATP synthase subunit delta, mitochondrial;
References:
1. Br J Anaesth. 2006; 97(5), 687-94.; 2. Anesthesiology. 2001; 94(6), 1026-33.; 3. Eur J Pharmacol. 2000; 395(2), 95-101.;