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Trioxsalen

Trimethylpsoralen,

Technical Data

Chemical name:Trioxsalen
Formula:C14H12O3
Molecular weight:228.2
CAS number:3902-71-4
SMILES:Cc1cc2cc3c(C)cc(=O)oc3c(C)c2o1

Cat. No. BRC0074

BRC0074

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Target:

DNA    SUBDNA   

Description:

Trioxsalen is a pigmenting photosensitizing agent used in conjunction with ultraviolet light in the treatment of vitiligo. Trioxsalen is pharmacologically inactive but when exposed to ultraviolet radiation or sunlight it is converted to its active metabolite to produce a beneficial reaction affecting the diseased tissue. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.

Targets:DNA
References:
1. Arch Dermatol. 2004 Dec; 140(12):1463-6.; 
2. Bioconjug Chem. 2007 Mar-Apr; 18(2):431-7.; 
3. Nucleic Acids Symp Ser (Oxf). 2005; (49):331-2.;