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Dicoumarol

Dicumarol, 3,3'-Methylenebis(4-hydroxycoumarin), Bishydroxycoumarin, NSC 17860, NSC 41834, NSC 221570

Technical Data

Chemical name:Dicoumarol
Formula:C19H12O6
Molecular weight:336.3
CAS number:66-76-2
SMILES:Oc1c(Cc2c(O)c3ccccc3oc2=O)c(=O)oc2ccccc12

Cat. No. BRC0361

BRC0361

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anticoagulants   

Target:

Enzymes    Dehydrogenase    Reductases   

Description:

Dicoumarol is a reductase inhibitor possessing anticoagulant properties. Dicoumarol also aids in apoptosis induction via stimulation of SAPK-JNK and NF-κB pathway blocking.

Targets:Vitamin K epoxide reductase complex subunit 1, NAD(P)H dehydrogenase [quinone] 1, Quinone oxidoreductase
References:
1. J. Biol. Chem. 1997; 30: 14200-14207.; 
2. J. Biol. Chem. 1998; 273, 20114-201120.; 
3. J. Biol. Chem. 1999; 274: 31150-31154.; 
4. J. Biol. Chem. 2000; 275: 5416-5424.; 
5. J. Biol. Chem. 2001; 276: 19244-19252.; 
6. Antioxid. Redox. Signal. 2003; 5:103-113.;