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Thalidomide

Thalomid, Distaval, Softenon, Talimol,

Technical Data

Chemical name:Thalidomide
Formula:C13H10N2O4
Molecular weight:258.2
CAS number:50-35-1
SMILES:O=C1N(C2CCC(=O)NC2=O)C(=O)c2ccccc12

Cat. No. BRC0121

BRC0121

Prices

1.0 mg $ 55.0
2.0 mg $ 56.0
5.0 mg $ 59.0
10.0 mg $ 78.0
20.0 mg $ 93.0
25.0 mg $ 100.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Target:

Kinases    Vascular endothelial growth factor (VEGF)    Enzymes    Kinases    Ligases    Enzyme-Linked Receptors    Cytokine receptors    Receptor Tyrosine Kinase    DNA    SUBDNA   

Description:

Thalidomide is an immunomodulatory agent with a spectrum of activity that is not fully characterized. Thalidomide is racemic — it contains both left and right handed isomers in equal amounts: one enantiomer is effective against morning sickness, and the other is teratogenic.

Targets:Protein cereblon, Tumor necrosis factor, Nuclear factor NF-kappa-B p105 subunit, DNA, Fibroblast growth factor receptor 2, Prostaglandin G/H synthase 2, Nuclear factor kappa-light-chain-enhancer of activated B cells, alpha1-acid glycoprotein
References:
1. J. Exp. Med. 1991; 173: 699-703.; 
2. Proc. Natl. Acad. Sci. U.S.A. 1994; 91: 4082-4085.; 
3. Proc. Natl. Acad. Sci. U.S.A. 1993; 90: 5974-5978.; 
4. Angiogenesis. 1999; 3: 201-204.; 
5. Semin. Oncol. 2001; 28: 536-542.;