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6-Mercaptopurine monohydrate

Purinethol, 6-Thiopurine,

Technical Data

Chemical name:6-Mercaptopurine monohydrate
Formula:C5H6N4OS
Molecular weight:170.2
CAS number:6112-76-1
SMILES:O.S=c1nc[nH]c2nc[nH]c12

Cat. No. BRC0102

BRC0102

Prices

1.0 mg $ 55.0
2.0 mg $ 56.0
5.0 mg $ 59.0
10.0 mg $ 78.0
20.0 mg $ 93.0
25.0 mg $ 100.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-cancer agents   

Target:

Enzymes    Dehydrogenase    DNA    SUBDNA    RNA   

Description:

Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias. It is an analogue of the purine bases adenine and hypoxanthine. It is not known exactly which of any one or more of the biochemical effects of mercaptopurine and its metabolites are directly or predominantly responsible for cell death.

Targets:HGPRT, GPAT, Inosine-5'-monophosphate dehydrogenase (Protein Group)
References:
1. Biochem J. 1981; 193:799-803.; 
2. Biochem Pharmacol. 1993; 45:1455-63.; 
3. Mol. Pharmacol. 1997; 51:414-21.;