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Guanabenz hydrochloride

NSC 68982, Wy 8678

Technical Data

Chemical name:Guanabenz hydrochloride
Formula:C8H9Cl3N4
Molecular weight:267.5
CAS number:23113-43-1
SMILES:Cl.NC(=N)NN=Cc1c(Cl)cccc1Cl

Cat. No. BRC0632

BRC0632

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Antihypertensive    Cardiovascular   

Target:

G-Protein-Coupled Receptors (GPCRs)    Angiotensin receptor    Enzymes    Proteases    Monoamine oxidases (MAO)    Proteases    Angiotensin-converting enzyme (ACE)   

Description:

Guanabenz is a centrally acting α-2 adrenergic agonist and IGRS (imidazoline I2 binding site) selective ligand, indicated for treatment of hypertension.

Targets:Angiotensin-converting enzyme, Monoamine oxidase, α2-Adrenoceptors, Imidazoline receptors,
References:
1. J. Pharmacol. Exp. Ther. 2003; 306(2), 646-657.; 
2. J. Biol. Chem. 1995; 270(17), 9856-61.; 
3. Biochem. Pharmacol. 1998; 55(7), 1035-1043.;