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Acetylcysteine

5052; NSC-111180; RK-0202; NAC; Mercapturic acid;

Technical Data

Chemical name:Acetylcysteine
Formula:C5H9NO3S
Molecular weight:163.2
CAS number:616-91-1
SMILES:CC(=O)N[C@@H](CS)C(O)=O

Cat. No. BRC0818

BRC0818

Prices

1.0 mg $ 64.0
2.0 mg $ 65.0
5.0 mg $ 68.0
10.0 mg $ 90.0
20.0 mg $ 99.0
25.0 mg $ 107.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Antiviral    Anti-infective   

Target:

Kinases    IκB kinase (IKK)    G-Protein-Coupled Receptors (GPCRs)    Glutamate receptor    Kinases    Ion Channels    Ligand-gated ion channels    Transporters    Ion Pumps    Neurotransmitter transporter   

Description:

Acetylcysteine (NAC) is an antioxidant and precursor of glutathione that has multiple effects in cells and animals. It is primarily used as a mucolytic agent and in the management of acetaminophen poisoning. It is essentially a prodrug that is converted to cysteine (in the intestine by the enzyme aminoacylase 1) and absorbed in the intestine into the bloodstream. As an antioxidant, NAC scavenges hydrogen peroxide, hydroxyl radical, and hypochlorous acid.

Targets:Glutathione synthetase; Cystine/glutamate transporter; NAPQI (N-acetyl-p-benzoquinone imine); Aminoacylase-1; Inhibitor of nuclear factor kappa-B kinase subunit beta; Inhibitor of nuclear factor kappa-B kinase subunit alpha; Glutamate receptor ionotropic, NMDA 2B; Glutamate receptor ionotropic, NMDA 1; Glutamate receptor ionotropic, NMDA 2A; Glutamate receptor ionotropic, NMDA 2D; Glutamate receptor ionotropic, NMDA 3A;
References:
1. J Psychiatry Neurosci. 2011; 36(2), 78-86.; 2. Chem Res Toxicol. 1998; 11(7), 800-9.; 3. Trends Neurosci. 2002; 25(9), 474-80.;