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Orphenadrine citrate

BS 5930, Biorphen, Brocadisipal, ORP, WS 2434

Technical Data

Chemical name:Orphenadrine citrate
Formula:C24H31NO8
Molecular weight:461.5
CAS number:4682-36-4
SMILES:OC(=O)CC(O)(CC(O)=O)C(O)=O.CN(C)CCOC(c1ccccc1)c1ccccc1C

Cat. No. BRC0660

BRC0660

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Muscle relaxant    CNS Agents    Neurotransmitter Agents    Antiparkinson   

Target:

G-Protein-Coupled Receptors (GPCRs)    Histamine receptor    Glutamate receptor    Ion Channels    Sodium channel    Ligand-gated ion channels    Transporters    Ion Pumps   

Description:

Orphenadrine Citrate is muscarinic receptor antagonist (pKi 7.39), H1 histamine receptor antagonist (pIC50 6.79), a muscle relaxant. It also inhibits the noradrenergic transporter and to block the NMDA receptor ion channel.

Targets:Glutamate receptor ionotropic, NMDA 2D, Glutamate receptor ionotropic, NMDA 1, Glutamate receptor ionotropic, NMDA 3B, Glutamate receptor ionotropic, NMDA 3A, Histamine H1 receptor, Sodium-dependent noradrenaline transporter, Sodium channel protein type 10 subunit alpha
References:
1. Mol. Pharmacol. 1990; 38, 6, 805.; 
2. J. Med. Chem. 2012; 55, 16, 7054.; 
3. Drug Metab. Dispos. 2003; 31, 5, 548.;