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Ganciclovir

GA2, Cytovene, Vitrasert, RS-21592, BW-759

Technical Data

Chemical name:Ganciclovir
Formula:C9H13N5O4
Molecular weight:255.2
CAS number:82410-32-0
SMILES:Nc1nc(=O)c2ncn(COC(CO)CO)c2[nH]1

Cat. No. BRC0233

BRC0233

Prices

1.0 mg $ 55.0
2.0 mg $ 56.0
5.0 mg $ 59.0
10.0 mg $ 78.0
20.0 mg $ 93.0
25.0 mg $ 100.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Antiviral    Anti-infective   

Target:

Kinases    Other kinases    Kinases    DNA    SUBDNA   

Description:

Ganciclovir is a synthetic nucleoside analogue of 2'-deoxyguanosine that inhibits replication of herpes viruses both in vitro and in vivo. Ganciclovir is a prodrug that is structurally similar to acyclovir.

Targets:DNA polymerase catalytic subunit, DNA, Thymidine kinase
References:
1. J. Gene Med. 2000; 2, 148.; 
2. Hum. Gene Ther. 2000; 11, 1569.; 
3. J. Virol. 1999; 73, 4786.; 
4. Cancer Res. 1999; 59, 669.; 
5. Proc. Natl. Acad. Sci. USA. 1999; 96, 6781.; 
6. C.R. Acad. Sci. III. 1999; 322, 151.; 
7. Cancer Res. 1998; 58, 3855.;