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Mitotane

Lysodren, Chlodithane, Mitotan, Chloditan, o,p'-DDD, NSC 38721, NCI-C04933

Technical Data

Chemical name:Mitotane
Formula:C14H10Cl4
Molecular weight:320.0
CAS number:53-19-0
SMILES:ClC(Cl)C(c1ccc(Cl)cc1)c1ccccc1Cl

Cat. No. BRC0169

BRC0169

Prices

1.0 mg $ 86.0
2.0 mg $ 88.0
5.0 mg $ 94.0
10.0 mg $ 121.0
20.0 mg $ 146.0
25.0 mg $ 159.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Anti-cancer agents   

Target:

Enzymes    Cytochrome P450 (CYP)   

Description:

A derivative of the insecticide dichlorodiphenyldichloroethane that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

Targets:Cytochrome P450 11B1, mitochondrial, Adrenodoxin, mitochondrial
References:
1. Cancer Treat Rep. 1980; 64: 909-913.; 
2. N. Engl. J. Med. 1990; 322: 1195-1201.;