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TC-DAPK 6

Technical Data

Chemical name:TC-DAPK 6
Formula:C17H12N2O2
Molecular weight:276.3
CAS number:315694-89-4
SMILES:O=C1OC(C=Cc2ccccc2)=NC1=Cc1cccnc1 |c:12|

Cat. No. BRC0476

BRC0476

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 140.0
25.0 mg $ 160.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Target:

Kinases    Mitogen-activated protein kinase (MAPK)    Vascular endothelial growth factor (VEGF)    Enzymes    Kinases    Phosphatases    Enzyme-Linked Receptors    Receptor protein serine/threonine kinases    Receptor Tyrosine Kinase   

Description:

TC-DAPK 6 is potent and selective, ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) (IC50 values are 69 and 225 nM for DAPK1 and DAPK3 respectively, when assayed with 10 μM ATP). Displays selectivity for DAPK1 over a range of 48 other kinases, including Abl, AMPK, Chk1, Met and Src (IC50 > 10 μM).

Targets:Death-associated protein kinase 3, Death-associated protein kinase 1, Protein phosphatase, Ribosomal protein S6 kinase beta-1, Mitogen-activated protein kinase 1, Vascular endothelial growth factor receptor 2, Fibroblast growth factor receptor 1, Casein kinase I isoform delta, Serine/threonine-protein kinase Sgk1
References:
1. J. Med. Chem. 2009; 52(22), 7323-7327.; 
2. Bioorg. Med. Chem. 2010; 18(7), 2728-2734.; 
3. Faming Zhuanli Shenqing. 2015; CN 104825450 A 20150812.;