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L-NAME hydrochloride

Technical Data

Chemical name:L-NAME hydrochloride
Formula:C7H16ClN5O4
Molecular weight:269.7
CAS number:51298-62-5
SMILES:Cl.COC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O

Cat. No. BRC1295

BRC1295

Prices

1.0 mg $ 57.0
2.0 mg $ 58.0
5.0 mg $ 62.0
10.0 mg $ 82.0
20.0 mg $ 98.0
25.0 mg $ 105.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Analgesics    Anti-cancer agents    Antihypertensive    Anti-Inflammatory   

Target:

Kinases    Vascular endothelial growth factor (VEGF)    Enzymes    Proteases    Kinases    Phosphodiesterases (PDE)    Enzyme-Linked Receptors    Receptor protein serine/threonine kinases    Cytokine receptors    Receptor Tyrosine Kinase    Proteases    Angiotensin-converting enzyme (ACE)   

Description:

L-NAME hydrochloride is a nonselective inhibitor of nitric oxide synthetases.

Targets:Nitric oxide synthase, brain; Nitric oxide synthase, endothelial; NADPH oxidase; G-protein coupled receptor family C group 6 member A; Na+/Ca2+ exchanger (NCX); Prostaglandin G/H synthase 2; Angiotensin-converting enzyme; Interleukin 1β; Interleukin 6; Tumor necrosis factor α; Phosphatidylinositol 3-kinase; Phosphodiesterase PDE5; Protein kinase Akt1; Vascular endothelial growth factor;
References:
1. Circulation. 2005; 112(5), 727-736.; 2. Eur. J. Pharmacol. 2013; 699(1-3), 23-32.; 3. Bioorganic Med. Chem. Lett. 2003; 13, 12, 1981 - 1984.;