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Fluoxetine Hydrochloride

Lilly 103472; Lilly 110 140; Prozac;

Technical Data

Chemical name:Fluoxetine Hydrochloride
Formula:C17H19ClF3NO
Molecular weight:345.8
CAS number:56296-78-7
SMILES:Cl.CNCCC(OC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1

Cat. No. BRC0838

BRC0838

Prices

1.0 mg $ 55.0
2.0 mg $ 56.0
5.0 mg $ 59.0
10.0 mg $ 78.0
20.0 mg $ 93.0
25.0 mg $ 100.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

CNS Agents    Neurotransmitter Agents    Antidepressive Agents   

Target:

Kinases    Cyclin-dependent protein kinases (CDK)    G-Protein-Coupled Receptors (GPCRs)    5-hydroxytryptamine receptor (5-HT receptor) inhibitors    Kinases    Ion Channels    Potassium channel    Ligand-gated ion channels    Transporters    Ion Pumps    Neurotransmitter transporter    Multidrug Transporter Inhibitors    P-glycoprotein/ABCB1   

Description:

Fluoxetine hydrochloride is the first-in-class antidepressant, selective serotonin-reuptake inhibitor. It displays a selectivity for the serotonin transporter (Kd = 0.81 nM) over the norepinephrine transporter (Kd = 240 nM) and the dopamine transporter (Kd = 3,600 nM). It is used in the clinical treatment of major depression as well as other psychiatric disorders.

Targets:Sodium-dependent serotonin transporter; Potassium voltage-gated channel subfamily H member 2; 5-hydroxytryptamine receptor 2C; Cyclin-dependent kinases regulatory subunit 1;
References:
1. Biochem Pharmacol. 2008; 75(10), 1924-34.; 2. Eur J Med Chem. 1997; 32, 3, 205 - 218.; 3. Life Sciences. 1995; 57, 8, 791 - 802.;