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(E, Z) - Teriflunomide

a 77-1726; Aubagio; HMR1726;

Technical Data

Chemical name:(E, Z) - Teriflunomide
Formula:C12H9F3N2O2
Molecular weight:270.2
CAS number:108605-62-5
SMILES:CC(O)=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F

Cat. No. BRC0203

BRC0203

Prices

1.0 mg $ 55.0
2.0 mg $ 56.0
5.0 mg $ 59.0
10.0 mg $ 78.0
20.0 mg $ 93.0
25.0 mg $ 100.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Analgesics    Anti-cancer agents    Anti-Inflammatory   

Target:

Enzymes    Dehydrogenase   

Description:

Teriflunomide is an immunomodulatory agent that decreases the amount of activated CNS lymphocytes, which results in anti-inflammatory and antiproliferative effects.

Targets:Dihydroorotate dehydrogenase (quinone), mitochondrial;
References:
1. Bioorg Med Chem Lett. 2011; 21, 24, 7268 - 7272.; 2. J Nat Prod. 2000; 63, 9, 1205 - 1209.; 3. J Pharm Pharmacol. 1999. 51, 11, 1267 - 1273.;